The spatial distribution of the signaling molecules that mediate cell-cell communication and
pattern formation is an important consideration for natural and engineered multicellular …

We investigate the boundary between chemotaxis driven by spatial estimation of gradients
and chemotaxis driven by temporal estimation. While it is well known that spatial chemotaxis …

When cells of the social amoeba Dictyostelium discoideum are starved of nutrients they start
to synthesize and secrete the chemical messenger and chemoattractant cyclic adenosine …

Cells sense various environmental cues and subsequently process intracellular signals to
decide their migration direction in many physiological and pathological processes. Although …

Quantitative examination of cellular motion and intercellullar interactions possesses
substantial relevance for both biology and medicine. However, the effects of intercellular …

This paper presents a model to study a hypothetical role of a simple nervous systems in
chemotaxis in early multicellular heterotrophs. The model views the organism as a network …

In this paper, a new (2+ 1)-dimensional chemotaxis model is introduced, the focus being the
understanding of influences of cooperative mechanisms from traction forces, long-range …

UNIVERSITY OF CALIFORNIA SAN DIEGO Signaling Pathways in Living Systems A
dissertation submitted in partial satisfaction of the Page 1 UNIVERSITY OF CALIFORNIA SAN …

Signalling and genetic networks underlie most biological processes and are often complex,
containing many highly connected components. Modelling these networks can provide …

Interdisciplinary investigation has the potential to advance all fields involved. In this
dissertation, three distinct fields of Quantitative Biology are discussed and advanced …