A classic physiologic response to systemic hypoxia is the increase in red blood cell
production. Hypoxia-inducible factors (HIFs) orchestrate this response by inducing cell-type …

Oxygen (O 2) is an essential nutrient that serves as a key substrate in cellular metabolism
and bioenergetics. In a variety of physiological and pathological states, organisms …

Astrocytes have important roles in the central nervous system (CNS) during health and
disease. Through genome-wide analyses we detected a transcriptional response to type I …

Improved understanding of the oxygen-dependent regulation of erythropoiesis has provided
new insights into the pathogenesis of anaemia associated with renal failure and has led to …

Small-molecule stabilizers of hypoxia inducible factor (HIF) are being developed for the
treatment of renal anaemia. These molecules inhibit prolyl hydroxylase domain-containing …

The hormone erythropoietin (Epo) maintains red blood cell mass by promoting the survival,
proliferation and differentiation of erythrocytic progenitors. Circulating Epo originates mainly …

The application of molecular techniques to exercise biology has provided novel insight into
the complexity and breadth of intracellular signaling networks involved in response to …

The kidney is a highly sensitive oxygen sensor and plays a central role in mediating the
hypoxic induction of red blood cell production. Efforts to understand the molecular basis of …

Osteoblasts are an important component of the hematopoietic microenvironment in bone.
However, the mechanisms by which osteoblasts control hematopoiesis remain unknown …

The kidney is the main physiologic source of erythropoietin (EPO) in the adult and responds
to decreases in tissue oxygenation with increased EPO production. Although studies in mice …