Lyme disease (Lyme borreliosis) is a tick-borne, zoonosis of adults and children caused by
genospecies of the Borrelia burgdorferi sensu lato complex. The ailment, widespread …

Lyme disease Borrelia are obligately parasitic, tick-transmitted, invasive, persistent bacterial
pathogens that cause disease in humans and non-reservoir vertebrates primarily through …

Borrelia burgdorferi (Bb) is the causative agent of Lyme disease in the United States, a
disease that can result in carditis, and chronic and debilitating arthritis and/or neurologic …

Maintenance of Borrelia burgdorferi within its enzootic cycle requires a complex regulatory
pathway involving the alternative σ factors RpoN and RpoS and two ancillary trans-acting …

The mammalian host responds to infection with Borrelia spirochetes through a highly
orchestrated immune defense involving innate and adaptive effector functions aimed toward …

Lyme disease is a complex tick-borne zoonosis that poses an escalating public health threat
in several parts of the world, despite sophisticated healthcare infrastructure and decades of …

Borrelia burgdorferi, the bacterial pathogen responsible for Lyme disease, modulates its
gene expression profile in response to the environments encountered throughout its tick …

ABSTRACT The Lyme disease spirochete, Borrelia burgdorferi, persists in nature by
alternatingly cycling between ticks and vertebrates. During each stage of the infectious …

The infectious cycle of Borrelia burgdorferi necessitates persistent infection of both
vertebrates and ticks, and efficient means of transmission between those two very different …

Lyme disease in the United States is most often caused by Borrelia burgdorferi sensu stricto.
After a tick bite, the patient may develop erythema migrans at that site. If hematogenous …