Discussion on structure classification and regulation function of histone deacetylase and their inhibitor
H Han, X Feng, T He, Y Wu, T He… - Chemical Biology & …, 2024 - Wiley Online Library
Epigenetic regulation of genes through posttranslational regulation of proteins is a well‐
explored approach for disease treatment, particularly in cancer chemotherapy. Histone …
explored approach for disease treatment, particularly in cancer chemotherapy. Histone …
Broad antagonism of coronaviruses nsp5 to evade the host antiviral responses by cleaving POLDIP3
Y Wu, M Li, J Tian, H Yan, Y Pan, H Shi, D Shi… - PLoS …, 2023 - journals.plos.org
Coronaviruses (CoVs) are a family of the largest RNA viruses that typically cause
respiratory, enteric, and hepatic diseases in animals and humans, imposing great threats to …
respiratory, enteric, and hepatic diseases in animals and humans, imposing great threats to …
Cleavage of HDAC6 to dampen its antiviral activity by nsp5 is a common strategy of swine enteric coronaviruses
ABSTRACT HDAC6, a structurally and functionally unique member of the histone
deacetylase (HDAC) family, is an important host factor that restricts viral infection. The broad …
deacetylase (HDAC) family, is an important host factor that restricts viral infection. The broad …
HDAC6 degrades nsp8 of porcine deltacoronavirus through deacetylation and ubiquitination to inhibit viral replication
Z Li, P Duan, R Qiu, L Fang, P Fang, S Xiao - Journal of Virology, 2023 - Am Soc Microbiol
Porcine deltacoronavirus (PDCoV) is an emerging swine enteropathogenic coronavirus that
has the potential to infect humans. Histone deacetylase 6 (HDAC6) is a unique type IIb …
has the potential to infect humans. Histone deacetylase 6 (HDAC6) is a unique type IIb …
Interaction of HDAC2 with SARS-CoV-2 NSP5 and IRF3 is not required for NSP5-mediated inhibition of type I interferon signaling pathway
Over the last 2 years, several global virus-host interactome studies have been published
with SARS-CoV-2 proteins with the purpose of better understanding how specific viral …
with SARS-CoV-2 proteins with the purpose of better understanding how specific viral …
Swine acute diarrhoea syndrome coronavirus (SADS-CoV) Nsp5 antagonizes type I interferon signaling by cleaving DCP1A
H Huang, C Zhao, X Lei, X Zhang, Y Li, T Lan… - Frontiers in …, 2023 - frontiersin.org
Swine acute diarrhoea syndrome coronavirus (SADS-CoV), which is a recently discovered
enteric coronavirus, is the major aetiological agent that causes severe clinical diarrhoea and …
enteric coronavirus, is the major aetiological agent that causes severe clinical diarrhoea and …
Neutrophil Elastase Degrades Histone Deacetylases and Sirtuin 1 in Primary Human Monocyte Derived Macrophages
Neutrophil elastase (NE) is taken up by macrophages, retains intracellular protease activity,
and induces a pro-inflammatory phenotype. However, the mechanism of NE-induced pro …
and induces a pro-inflammatory phenotype. However, the mechanism of NE-induced pro …
组蛋白去乙酰化酶参与畜禽病毒感染的作用及机制
谭磊， 彭小烨， 王开心， 黄小久， 张帆， 禹思宇 - 中国畜牧兽医, 2024 - chvm.net
畜禽在养殖过程中易受病毒感染, 给养殖业造成严重的经济损失, 其中部分畜禽病毒(如乙脑病毒
和口蹄疫病毒) 属于人兽共患性病原, 对养殖工作人员及消费者健康也可造成潜在威胁. 因此 …
和口蹄疫病毒) 属于人兽共患性病原, 对养殖工作人员及消费者健康也可造成潜在威胁. 因此 …