[PDF][PDF] The lymphatic vasculature in the 21st century: novel functional roles in homeostasis and disease

G Oliver, J Kipnis, GJ Randolph, NL Harvey - Cell, 2020 - cell.com
Mammals have two specialized vascular circulatory systems: the blood vasculature and the
lymphatic vasculature. The lymphatic vasculature is a unidirectional conduit that returns …

Vascular heterogeneity and specialization in development and disease

M Potente, T Mäkinen - Nature Reviews Molecular Cell Biology, 2017 - nature.com
Blood and lymphatic vessels pervade almost all body tissues and have numerous essential
roles in physiology and disease. The inner lining of these networks is formed by a single …

[HTML][HTML] Lymphatic vessel network structure and physiology

JW Breslin, Y Yang, JP Scallan, RS Sweat… - Comprehensive …, 2018 - ncbi.nlm.nih.gov
The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue,
which has the holistic function to maintain the local physiologic environment for every cell in …

Lymphatic system in cardiovascular medicine

A Aspelund, MR Robciuc, S Karaman… - Circulation …, 2016 - Am Heart Assoc
The mammalian circulatory system comprises both the cardiovascular system and the
lymphatic system. In contrast to the blood vascular circulation, the lymphatic system forms a …

The lymphatic vasculature in disease

K Alitalo - Nature medicine, 2011 - nature.com
Blood vessels form a closed circulatory system, whereas lymphatic vessels form a one-way
conduit for tissue fluid and leukocytes. In most vertebrates, the main function of lymphatic …

Lymphatic vascular morphogenesis in development, physiology, and disease

S Schulte-Merker, A Sabine, TV Petrova - Journal of Cell Biology, 2011 - rupress.org
The lymphatic vasculature constitutes a highly specialized part of the vascular system that is
essential for the maintenance of interstitial fluid balance, uptake of dietary fat, and immune …

[HTML][HTML] Vascular endothelial cell specification in health and disease

C Marziano, G Genet, KK Hirschi - Angiogenesis, 2021 - Springer
There are two vascular networks in mammals that coordinately function as the main supply
and drainage systems of the body. The blood vasculature carries oxygen, nutrients …

Regulation of endothelial cell differentiation and specification

KL Marcelo, LC Goldie, KK Hirschi - Circulation research, 2013 - Am Heart Assoc
The circulatory system is the first organ system to develop in the vertebrate embryo and is
critical throughout gestation for the delivery of oxygen and nutrients to, as well as removal of …

[HTML][HTML] The evolving cardiac lymphatic vasculature in development, repair and regeneration

K Klaourakis, JM Vieira, PR Riley - Nature Reviews Cardiology, 2021 - nature.com
The lymphatic vasculature has an essential role in maintaining normal fluid balance in
tissues and modulating the inflammatory response to injury or pathogens. Disruption of …

Lymphatic vessels arise from specialized angioblasts within a venous niche

J Nicenboim, G Malkinson, T Lupo, L Asaf, Y Sela… - Nature, 2015 - nature.com
How cells acquire their fate is a fundamental question in developmental and regenerative
biology. Multipotent progenitors undergo cell-fate restriction in response to cues from the …