Abstract Calcium (Ca 2+) is an universal second messenger that regulates the most
important activities of all eukaryotic cells. It is of critical importance to neurons as it …

Neuronal subpopulations display differential vulnerabilities to disease, but the factors that
determine their susceptibility are poorly understood. Toxic increases in intracellular calcium …

Background A reduction of the number of parvalbumin (PV)-immunoreactive (PV+)
GABAergic interneurons or a decrease in PV immunoreactivity was reported in several …

Gene mutations and gene copy number variants are associated with autism spectrum
disorders (ASDs). Affected gene products are often part of signaling networks implicated in …

The sensation of pain is associated with increased mortality, but it is unknown whether pain
perception can directly affect aging. We find that mice lacking TRPV1 pain receptors are …

For precisely regulating intracellular Ca2+ signals in a time-and space-dependent manner,
cells make use of various components of the “Ca2+ signaling toolkit,” including Ca2+ entry …

A number of age-associated neurodegenerative diseases, including Alzheimer's disease
(AD), Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS), possess a shared …

A hallmark feature of Huntington's disease pathology is the atrophy of brain regions
including, but not limited to, the striatum. Though MRI studies have identified structural CNS …

Fragile X syndrome (FXS) patients do not make the fragile X mental retardation protein
(FMRP). The absence of FMRP causes dysregulated translation, abnormal synaptic …

The transient receptor potential vanilloid 1 (TRPV1) protein is a pain receptor that elicits a
hot sensation when an organism eats the capsaicin of red chili peppers. This calcium (Ca2+) …