Synapses are the sites of neuron-to-neuron communication and form the basis of the neural
circuits that underlie all animal cognition and behavior. Chemical synapses are specialized …

The small GTPases from the Ras superfamily play crucial roles in basic cellular processes
during practically the entire process of neurodevelopment, including neurogenesis …

Sensory experience remodels neural circuits in the early postnatal brain through
mechanisms that remain to be elucidated. Applying a new method of ultrastructural analysis …

The structural characterization of protein complexes in their native environment is
challenging but crucial for understanding the mechanisms that mediate cellular processes …

Abstract The Ral guanosine triphosphatases (GTPases), RalA and RalB, are members of the
Ras superfamily of small GTPases. Research on Ral GTPases and their functions over the …

Surface levels of membrane proteins are determined by a dynamic balance between
exocytosis-mediated surface delivery and endocytosis-dependent retrieval from the cell …

At the Drosophila neuromuscular junction, inhibition of postsynaptic glutamate receptors
activates retrograde signaling that precisely increases presynaptic neurotransmitter release …

Cell polarization is essential for neuronal development in both the embryonic and postnatal
brain. Here, using primary cultures, in vivo postnatal electroporation and conditional genetic …

In this review, we discuss the synaptic aspects of Tau pathology occurring during
Alzheimer's disease (AD) and how this may relate to memory impairment, a major hallmark …

Postsynaptic compartments can be specifically modulated during various forms of synaptic
plasticity, but it is unclear whether this precision is shared at presynaptic terminals …