Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Obesity and osteoporosis are two alarming health disorders prominent among middle and
old age populations, and the numbers of those affected by these two disorders are …

Mortality in children with severe malnutrition is strongly related to signs of metabolic
dysfunction, such as hypoglycemia. Lower circulating tryptophan levels in children with …

Disruption of mitochondrial function is a common feature of inherited mitochondrial diseases
(mitochondriopathies) and many other infectious and non-infectious diseases including viral …

The protein deacetylase SIRT 1 has been recognized to exert its protective effect by directly
deacetylasing histone and many other transcriptional factors including p53. However, the …

Growth hormone (GH) is a peptide hormone secreted from the pituitary gland with pleiotropic
metabolic effects. 1, 2 It is essential for induction of postnatal longitudinal growth and this …

Resveratrol has long been proposed as being beneficial to human health across multiple
morbidities, yet there is currently no conclusive clinical evidence to advocate its …

Objective Chronic obstructive pulmonary disease (COPD) is often associated with
sarcopenia, and systemic inflammation is an underlying pathogenesis of COPD. In this …

Objective Growth hormone (GH) stimulates lipolysis, but the underlying mechanisms remain
incompletely understood. We examined the effect of GH on the expression of lipolytic …

Many aspects of physiological functions are controlled by the hypothalamus, a brain region
that connects the neuroendocrine system to whole-body metabolism. Growth hormone (GH) …