The nature of microglia fascinated many prominent researchers in the 19th and early 20th
centuries, and in a classic treatise in 1932, Pio del Rio-Hortega formulated a number of …

▪ Abstract Microglia are the principal immune cells in the central nervous system (CNS) and
have a critical role in host defense against invading microorganisms and neoplastic cells …

N-methyl-d-aspartate (NMDA) receptor antagonists have therapeutic potential in numerous
CNS disorders ranging from acute neurodegeneration (eg stroke and trauma), chronic …

▪ Abstract Platelet-activating factor (PAF) is a phospholipid with potent, diverse physiological
actions, particularly as a mediator of inflammation. The synthesis, transport, and degradation …

This book grew out of a scientific review, originally published in Microbiological Reviews. It
has been updated and expanded-now citing more than 2100 references (100 pages of the …

Three enzyme systems, cyclooxygenases that generate prostaglandins, lipoxygenases that
form hydroxy derivatives and leukotrienes, and epoxygenases that give rise to …

Infection with the human immunodeficiency virus-1 (HIV-1) can induce severe and
debilitating neurological problems that include behavioral abnormalities, motor dysfunction …

Prevention and treatment of HAND requires strategies aimed at suppressing CNS HIV
replication and effects of systemic and CNS inflammation in aging and substance-abusing …

Proinflammatory cytokines, tumour necrosis factor (TNF)-α, interferon (IFN)-γ and interleukin
(IL)-6, have multiple effects in the central nervous system (CNS) not strictly cytotoxic being …

Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a
biologically active phospholipid mediator. Although PAF was initially recognized for its …