ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Blood-brain barrier disruption occurs in the early stages of Alzheimer's disease. Recent
studies indicate a link between blood-brain barrier dysfunction and cognitive decline and …

Alzheimer's disease (AD) is the most frequent type of dementia characterized by the
deposition of amyloid beta (Aβ) plaque and tau-neurofibrillary tangles (TNTs) in the brain …

Oxidative stress is associated with the progression of Alzheimer's disease (AD). Reactive
oxygen species can modify lipids, DNA, RNA, and proteins in the brain. The products of their …

The blood–brain barrier (BBB) is a fundamental structure that protects the composition of the
brain by determining which ions, metabolites, and nutrients are allowed to enter the brain …

Proprioception is sensed by muscle spindles for precise locomotion and body posture.
Unlike the neuromuscular junction (NMJ) for muscle contraction which has been well …

Sleep plays an essential role in all studied animals with a nervous system. However, sleep
deprivation leads to various pathological changes and neurobehavioral problems …

The low-density-lipoprotein receptors represent a family of pleiotropic cell surface receptors
involved in lipid homeostasis, cell migration, proliferation and differentiation. The family …

The rise of life expectancy of the human population is accompanied by the drastic increases
of age‐associated diseases, in particular Alzheimer's disease (AD), and underscores the …

Background Vacuolar sorting protein 35 (VPS35), a key component of the retromer, plays an
essential role in selectively retrieval of transmembrane proteins from endosomes to trans …