Oxidative stress and neural dysfunction in gastrointestinal diseases: can stem cells offer a solution?
Oxidative stress is involved in many gastrointestinal (GI) disorders as either the primary
pathogenesis (radiation, chemotherapy, toxicity, ischemia-reperfusion) or a secondary …
pathogenesis (radiation, chemotherapy, toxicity, ischemia-reperfusion) or a secondary …
Opportunities for novel diagnostic and cell-based therapies for Hirschsprung disease
Despite significant progress in our understanding of the etiology and pathophysiology of
Hirschsprung disease (HSCR), early and accurate diagnosis and operative management …
Hirschsprung disease (HSCR), early and accurate diagnosis and operative management …
Schwann cells in the aganglionic colon of Hirschsprung disease can generate neurons for regenerative therapy
Cell therapy offers the potential to replace the missing enteric nervous system (ENS) in
patients with Hirschsprung disease (HSCR) and to restore gut function. The Schwann cell …
patients with Hirschsprung disease (HSCR) and to restore gut function. The Schwann cell …
Schwann cells in the subcutaneous adipose tissue have neurogenic potential and can be used for regenerative therapies
Stem cell therapies for nervous system disorders are hindered by a lack of accessible
autologous sources of neural stem cells (NSCs). In this study, neural crest–derived Schwann …
autologous sources of neural stem cells (NSCs). In this study, neural crest–derived Schwann …
[HTML][HTML] Single-cell multiome sequencing clarifies enteric glial diversity and identifies an intraganglionic population poised for neurogenesis
The enteric nervous system (ENS) consists of glial cells (EGCs) and neurons derived from
neural crest precursors. EGCs retain capacity for large-scale neurogenesis in culture, and in …
neural crest precursors. EGCs retain capacity for large-scale neurogenesis in culture, and in …
Bone marrow-derived mesenchymal stem cells mitigate chronic colitis and enteric neuropathy via anti-inflammatory and anti-oxidative mechanisms
R Stavely, AM Robinson, S Fraser, RT Filippone… - Scientific Reports, 2024 - nature.com
Current treatments for inflammatory bowel disease (IBD) are often inadequate due to limited
efficacy and toxicity, leading to surgical resection in refractory cases. IBD's broad and …
efficacy and toxicity, leading to surgical resection in refractory cases. IBD's broad and …
Dickkopf1 induces enteric neurogenesis and gliogenesis in vitro if apoptosis is evaded
M Scharr, S Scherer, B Hirt, PH Neckel - Communications Biology, 2023 - nature.com
Neurogenesis in the postnatal enteric nervous system (ENS) is controversially discussed.
Yet, deciphering the regenerative potential of the ENS is essential for our understanding and …
Yet, deciphering the regenerative potential of the ENS is essential for our understanding and …
A distinct transcriptome characterizes neural crest-derived cells at the migratory wavefront during enteric nervous system development
Enteric nervous system development relies on intestinal colonization by enteric neural crest-
derived cells (ENCDCs). This is driven by a population of highly migratory and proliferative …
derived cells (ENCDCs). This is driven by a population of highly migratory and proliferative …
Transplanted ENSCs form functional connections with intestinal smooth muscle and restore colonic motility in nNOS-deficient mice
Background Enteric neuropathies, which result from abnormalities of the enteric nervous
system, are associated with significant morbidity and high health-care costs, but current …
system, are associated with significant morbidity and high health-care costs, but current …
Optogenetic activation of cholinergic enteric neurons reduces inflammation in experimental colitis
Background & Aims Intestinal inflammation is associated with loss of enteric cholinergic
neurons. Given the systemic anti-inflammatory role of cholinergic innervation, we …
neurons. Given the systemic anti-inflammatory role of cholinergic innervation, we …