Membrane fusion, one of the most fundamental processes in life, occurs when two separate
lipid membranes merge into a single continuous bilayer. Fusion reactions share common …

▪ Abstract We review the physical properties of phosphatidylinositol 4, 5-bisphosphate (PIP2)
that determine both its specific interactions with protein domains of known structure and its …

The past two years have seen an explosion in the structural understanding of the endosomal
sorting complex required for transport (ESCRT) machinery that facilitates the trafficking of …

The ESCRT machinery consists of the peripheral membrane protein complexes ESCRT-0,-I,-
II,-III, and Vps4–Vta1, and the ALIX homodimer. The ESCRT system is required for …

▪ Abstract Clathrin-coated vesicles (CCVs) are responsible for the transport of proteins
between various compartments of the secretory and endocytic systems. Clathrin forms a …

Domains or modules known to bind phosphoinositides have increased dramatically in
number over the past few years, and are found in proteins involved in intracellular trafficking …

Phosphoinositides (PtdInsPs) play critical roles in cytoplasmic signal transduction pathways.
However, their functions in the nucleus are unclear, as specific nuclear receptors for …

Membrane budding is a key step in vesicular transport, multivesicular body biogenesis, and
enveloped virus release. These events range from those that are primarily protein driven …

Recent research has provided an abundance of new information on membrane
biochemistry. Now more than ever, it is essential to update our current understanding of …

The ESCRT complexes and associated proteins comprise a major pathway for the
lysosomal degradation of transmembrane proteins and are critical for receptor …