The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …

In mammals, hematopoietic stem cells (HSCs) engage in hematopoiesis throughout adult
life within the bone marrow, where they produce the mature cells necessary to maintain …

Matrix metalloproteinases (MMPs) participate from the initial phases of cancer onset to the
settlement of a metastatic niche in a second organ. Their role in cancer progression is …

Endothelial cells that line capillaries are not just passive conduits for delivering blood.
Tissue-specific endothelium establishes specialized vascular niches that deploy sets of …

Bone marrow endothelial cells (BMECs) form a network of blood vessels that regulate both
leukocyte trafficking and haematopoietic stem and progenitor cell (HSPC) maintenance …

Niches are local tissue microenvironments that maintain and regulate stem cells.
Haematopoiesis provides a model for understanding mammalian stem cells and their …

The epithelial‐mesenchymal transition (EMT) is a transformation process mandatory for the
local and distant progression of many malignant tumors, including hepatocellular carcinoma …

Activation of the tumor and stromal cell-driven angiogenic program is one of the first
requirements in the tumor ecosystem for growth and dissemination. The understanding of …

Blood vessels deliver oxygen and nutrients to every part of the body, but also nourish
diseases such as cancer. Over the past decade, our understanding of the molecular …

Research on matrix metalloproteinases (MMPs) and in particular on gelatinase B, alias MMP-
9, has grown exponentially in the decade 2003–2012. Structural details about flexibility of …