[HTML][HTML] Diet-induced dysbiosis of the intestinal microbiota and the effects on immunity and disease

K Brown, D DeCoffe, E Molcan, DL Gibson - Nutrients, 2012 - mdpi.com
The gastrointestinal (GI) microbiota is the collection of microbes which reside in the GI tract
and represents the largest source of non-self antigens in the human body. The GI tract …

Gut microbiota, probiotics and diabetes

AC Gomes, AA Bueno, RGM de Souza, JF Mota - Nutrition journal, 2014 - Springer
Diabetes is a condition of multifactorial origin, involving several molecular mechanisms
related to the intestinal microbiota for its development. In type 2 diabetes, receptor activation …

Akkermansia muciniphila induces gut microbiota remodelling and controls islet autoimmunity in NOD mice

A Hänninen, R Toivonen, S Pöysti, C Belzer, H Plovier… - Gut, 2018 - gut.bmj.com
Objective Intestinal microbiota is implicated in the pathogenesis of autoimmune type 1
diabetes in humans and in non-obese diabetic (NOD) mice, but evidence on its causality …

Microbiota alteration is associated with the development of stress-induced despair behavior

IA Marin, JE Goertz, T Ren, SS Rich… - Scientific reports, 2017 - nature.com
Depressive disorders often run in families, which, in addition to the genetic component, may
point to the microbiome as a causative agent. Here, we employed a combination of …

[HTML][HTML] Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice

AE Livanos, TU Greiner, P Vangay, W Pathmasiri… - Nature …, 2016 - nature.com
The early life microbiome plays important roles in host immunological and metabolic
development. Because the incidence of type 1 diabetes (T1D) has been increasing …

Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes

CT Brown, AG Davis-Richardson, A Giongo, KA Gano… - PloS one, 2011 - journals.plos.org
Recent studies have suggested a bacterial role in the development of autoimmune disorders
including type 1 diabetes (T1D). Over 30 billion nucleotide bases of Illumina shotgun …

Association of early exposure of probiotics and islet autoimmunity in the TEDDY study

U Uusitalo, X Liu, J Yang, CA Aronsson… - JAMA …, 2016 - jamanetwork.com
Importance Probiotics have been hypothesized to affect immunologic responses to
environmental exposures by supporting healthy gut microbiota and could therefore …

Alterations in intestinal microbiota correlate with susceptibility to type 1 diabetes

AK Alkanani, N Hara, PA Gottlieb, D Ir… - Diabetes, 2015 - Am Diabetes Assoc
We tested the hypothesis that alterations in the intestinal microbiota are linked with the
progression of type 1 diabetes (T1D). Herein, we present results from a study performed in …

Impact of gut microbiota on diabetes mellitus

G Blandino, R Inturri, F Lazzara, M Di Rosa… - Diabetes & …, 2016 - Elsevier
Various functions of the gut are regulated by sophisticated interactions among its functional
elements, including the gut microbiota. These microorganisms play a crucial role in …

Th17 cells in immunity and autoimmunity

SK Bedoya, B Lam, K Lau… - Journal of Immunology …, 2013 - Wiley Online Library
Th17 and IL‐17 play important roles in the clearance of extracellular bacterial and fungal
infections. However, strong evidence also implicates the Th17 lineage in several …