[HTML][HTML] Diet-induced dysbiosis of the intestinal microbiota and the effects on immunity and disease
The gastrointestinal (GI) microbiota is the collection of microbes which reside in the GI tract
and represents the largest source of non-self antigens in the human body. The GI tract …
and represents the largest source of non-self antigens in the human body. The GI tract …
Gut microbiota, probiotics and diabetes
Diabetes is a condition of multifactorial origin, involving several molecular mechanisms
related to the intestinal microbiota for its development. In type 2 diabetes, receptor activation …
related to the intestinal microbiota for its development. In type 2 diabetes, receptor activation …
Akkermansia muciniphila induces gut microbiota remodelling and controls islet autoimmunity in NOD mice
A Hänninen, R Toivonen, S Pöysti, C Belzer, H Plovier… - Gut, 2018 - gut.bmj.com
Objective Intestinal microbiota is implicated in the pathogenesis of autoimmune type 1
diabetes in humans and in non-obese diabetic (NOD) mice, but evidence on its causality …
diabetes in humans and in non-obese diabetic (NOD) mice, but evidence on its causality …
Microbiota alteration is associated with the development of stress-induced despair behavior
Depressive disorders often run in families, which, in addition to the genetic component, may
point to the microbiome as a causative agent. Here, we employed a combination of …
point to the microbiome as a causative agent. Here, we employed a combination of …
[HTML][HTML] Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice
AE Livanos, TU Greiner, P Vangay, W Pathmasiri… - Nature …, 2016 - nature.com
The early life microbiome plays important roles in host immunological and metabolic
development. Because the incidence of type 1 diabetes (T1D) has been increasing …
development. Because the incidence of type 1 diabetes (T1D) has been increasing …
Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes
Recent studies have suggested a bacterial role in the development of autoimmune disorders
including type 1 diabetes (T1D). Over 30 billion nucleotide bases of Illumina shotgun …
including type 1 diabetes (T1D). Over 30 billion nucleotide bases of Illumina shotgun …
Association of early exposure of probiotics and islet autoimmunity in the TEDDY study
U Uusitalo, X Liu, J Yang, CA Aronsson… - JAMA …, 2016 - jamanetwork.com
Importance Probiotics have been hypothesized to affect immunologic responses to
environmental exposures by supporting healthy gut microbiota and could therefore …
environmental exposures by supporting healthy gut microbiota and could therefore …
Alterations in intestinal microbiota correlate with susceptibility to type 1 diabetes
AK Alkanani, N Hara, PA Gottlieb, D Ir… - Diabetes, 2015 - Am Diabetes Assoc
We tested the hypothesis that alterations in the intestinal microbiota are linked with the
progression of type 1 diabetes (T1D). Herein, we present results from a study performed in …
progression of type 1 diabetes (T1D). Herein, we present results from a study performed in …
Impact of gut microbiota on diabetes mellitus
Various functions of the gut are regulated by sophisticated interactions among its functional
elements, including the gut microbiota. These microorganisms play a crucial role in …
elements, including the gut microbiota. These microorganisms play a crucial role in …
Th17 cells in immunity and autoimmunity
SK Bedoya, B Lam, K Lau… - Journal of Immunology …, 2013 - Wiley Online Library
Th17 and IL‐17 play important roles in the clearance of extracellular bacterial and fungal
infections. However, strong evidence also implicates the Th17 lineage in several …
infections. However, strong evidence also implicates the Th17 lineage in several …