Innate immune dysfunction and neuroinflammation in autism spectrum disorder (ASD)

HK Hughes, RJ Moreno, P Ashwood - Brain, behavior, and immunity, 2023 - Elsevier
Autism spectrum disorder (ASD) is a highly heterogeneous neurodevelopmental disorder
characterized by communication and social behavior deficits. The presence of restricted and …

Peripheral immune cells and perinatal brain injury: a double-edged sword?

J Herz, I Bendix, U Felderhoff-Müser - Pediatric research, 2022 - nature.com
Perinatal brain injury is the leading cause of neurological mortality and morbidity in
childhood ranging from motor and cognitive impairment to behavioural and neuropsychiatric …

[HTML][HTML] Monocytes promote acute neuroinflammation and become pathological microglia in neonatal hypoxic-ischemic brain injury

HR Chen, CW Chen, YM Kuo, B Chen, IS Kuan… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: Monocytes belong to the mononuclear phagocyte system and are immune
responders to tissue injury and infection. There were also reports of monocytes transforming …

Immune activation during pregnancy exacerbates ASD-related alterations in Shank3-deficient mice

E Atanasova, AP Arévalo, I Graf, R Zhang, J Bockmann… - Molecular Autism, 2023 - Springer
Background Autism spectrum disorder (ASD) is mainly characterized by deficits in social
interaction and communication and repetitive behaviors. Known causes of ASD are …

Complex neuroimmune involvement in neurodevelopment: a mini-review

MC Monet, N Quan - Journal of Inflammation Research, 2023 - Taylor & Francis
It is increasingly evident that cells and molecules of the immune system play significant roles
in neurodevelopment. As perinatal infection is associated with the development of …

The impact of Microglia on Neurodevelopment and Brain function in Autism

Y Luo, Z Wang - Biomedicines, 2024 - mdpi.com
Microglia, as one of the main types of glial cells in the central nervous system (CNS), are
widely distributed throughout the brain and spinal cord. The normal number and function of …

The Homer1 family of proteins at the crossroad of dopamine-glutamate signaling: An emerging molecular “Lego” in the pathophysiology of psychiatric disorders. A …

A de Bartolomeis, A Barone, EF Buonaguro… - Neuroscience & …, 2022 - Elsevier
Once considered only scaffolding proteins at glutamatergic postsynaptic density (PSD),
Homer1 proteins are increasingly emerging as multimodal adaptors that integrate different …

Oxytocin and microglia in the development of social behaviour

A Gonzalez, EAD Hammock - … Transactions of the …, 2022 - royalsocietypublishing.org
Oxytocin is a well-established regulator of social behaviour. Microglia, the resident immune
cells of the central nervous system, regulate brain development and maintenance in health …

Deletion of the autism-associated protein SHANK3 abolishes structural synaptic plasticity after brain trauma

C Urrutia-Ruiz, D Rombach, S Cursano… - International journal of …, 2022 - mdpi.com
Autism spectrum disorders (ASDs) are characterized by repetitive behaviors and
impairments of sociability and communication. About 1% of ASD cases are caused by …

The impact of maternal immune activation on GABAergic interneuron development: A systematic review of rodent studies and their translational implications

B Gillespie, S Panthi, S Sundram, RA Hill - Neuroscience & Biobehavioral …, 2023 - Elsevier
Mothers exposed to infections during pregnancy disproportionally birth children who
develop autism and schizophrenia, disorders associated with altered GABAergic function …