Modulation of hyaluronan signaling as a therapeutic target in human disease

S Garantziotis - Pharmacology & therapeutics, 2022 - Elsevier
The extracellular matrix is an active participant, modulator and mediator of the cell, tissue,
organ and organismal response to injury. Recent research has highlighted the role of …

Alcohol-related liver disease (ALD): current perspectives on pathogenesis, therapeutic strategies, and animal models

X Hong, S Huang, H Jiang, Q Ma, J Qiu… - Frontiers in …, 2024 - frontiersin.org
Alcohol-related liver disease (ALD) is a major cause of morbidity and mortality worldwide. It
encompasses conditions such as fatty liver, alcoholic hepatitis, chronic hepatitis with liver …

Molecular weight and gut microbiota determine the bioavailability of orally administered hyaluronic acid

M Šimek, K Turková, M Schwarzer, K Nešporová… - Carbohydrate …, 2023 - Elsevier
The ability of hyaluronan as a dietary supplement to increase skin moisture and relieve knee
pain has been demonstrated in several clinical studies. To understand the mechanism of …

Hyaluronan-induced alterations of the gut microbiome protects mice against Citrobacter rodentium infection and intestinal inflammation

T Mao, CW Su, Q Ji, CY Chen, R Wang… - Gut …, 2021 - Taylor & Francis
Hyaluronan is a glycosaminoglycan polymer that has been shown to play an important role
in homeostasis of the gastrointestinal tract. However, its mechanistic significance in …

Electrospun Food Polysaccharides Loaded with Bioactive Compounds: Fabrication, Release, and Applications

Z Lin, H Chen, S Li, X Li, J Wang, S Xu - Polymers, 2023 - mdpi.com
Food polysaccharides are well acclaimed in the field of delivery systems due to their natural
safety, biocompatibility with the human body, and capability of incorporating/releasing …

The role of hyaluronan treatment in intestinal innate host defense

Y Kim, CA de la Motte - Frontiers in Immunology, 2020 - frontiersin.org
Hyaluronan (HA) is best known as an abundantly present extracellular matrix component
found throughout the body of all vertebrates, including humans. Recent evidence, however …

35kDa hyaluronan ameliorates ethanol driven loss of anti-microbial defense and intestinal barrier integrity in a TLR4-dependent manner

S Ray, E Huang, GA West, M Mrdjen, MR McMullen… - Matrix Biology, 2023 - Elsevier
Acute and chronic alcohol exposure compromise intestinal epithelial integrity, due to
reduced expression of anti-microbial peptides (AMP) and loss of tight junction integrity …

Nanocosmetics: future perspective

P Morganti, HD Chen, G Morganti - Nanocosmetics, 2020 - Elsevier
The continuous degradation and depletion of the planet'natural raw materials with the
increasing production and consume of nonbiodegradable plastics, used as packaging …

Characterization, bioactivity, and biodistribution of 35 kDa hyaluronan fragment

MA Gantumur, X Jia, JH Hui, C Barber, L Wan… - Life, 2024 - mdpi.com
It has been reported that hyaluronic acid (HA) with a 35 kDa molecular weight (HA35) acts
biologically to protect tissue from injury, but its biological properties are not yet fully …

[HTML][HTML] Low molecular weight 35 kDa hyaluronan fragment HA35 in the treatment of bone metastasis pain: A case report

Z Zhang, X Jia, D Treger, M Hui - Medicine, 2024 - journals.lww.com
Interventions: Treatment involved subcutaneous injection into the deep fat tissue layer of the
abdomen. A subcutaneous injection of 100 mg/5 mL of HA35 was administered once into …