Affibody molecules as targeting vectors for PET imaging

V Tolmachev, A Orlova - Cancers, 2020 - mdpi.com
Affibody molecules are small (58 amino acids) engineered scaffold proteins that can be
selected to bind to a large variety of proteins with a high affinity. Their small size and high …

Advances in BODIPY photocleavable protecting groups

PK Singh, P Majumdar, SP Singh - Coordination Chemistry Reviews, 2021 - Elsevier
Photoactivatable protecting groups (PPGs) or caged compounds are beneficial tools for
spatiotemporal controlled release of bioagents, fluorescent probes, polymerization initiators …

Near-infrared photoactivatable nitric oxide donors with integrated photoacoustic monitoring

EY Zhou, HJ Knox, CJ Reinhardt… - Journal of the …, 2018 - ACS Publications
Photoacoustic (PA) tomography is a noninvasive technology that utilizes near-infrared (NIR)
excitation and ultrasonic detection to image biological tissue at centimeter depths. While …

Tracking antibody distribution with near-infrared fluorescent dyes: impact of dye structure and degree of labeling on plasma clearance

C Cilliers, I Nessler, N Christodolu… - Molecular …, 2017 - ACS Publications
Monoclonal antibodies labeled with near-infrared (NIR) fluorophores have potential use in
disease detection, intraoperative imaging, and pharmacokinetic characterization of …

Tumor drug penetration measurements could be the neglected piece of the personalized cancer treatment puzzle

IH Bartelink, EF Jones… - Clinical …, 2019 - Wiley Online Library
Precision medicine aims to use patient genomic, epigenomic, specific drug dose, and other
data to define disease patterns that may potentially lead to an improved treatment outcome …

The key role of sulfation and branching on fucoidan antitumor activity

C Oliveira, AS Ferreira… - Macromolecular …, 2017 - Wiley Online Library
There is an urgent need for antitumor bioactive agents with minimal or no side effects over
normal adjacent cells. Fucoidan is a marine‐origin polymer with known antitumor activity …

Molecular imaging of innate immunity and immunotherapy

W Xia, N Singh, S Goel, S Shi - Advanced Drug Delivery Reviews, 2023 - Elsevier
The innate immune system plays a key role as the first line of defense in various human
diseases including cancer, cardiovascular and inflammatory diseases. In contrast to tissue …

Computational transport analysis of antibody-drug conjugate bystander effects and payload tumoral distribution: implications for therapy

E Khera, C Cilliers, S Bhatnagar… - Molecular Systems Design …, 2018 - pubs.rsc.org
Antibody drug conjugates (ADCs) have a proven clinical record with four FDA approved
drugs and dozens more in clinical trials. However, a better understanding of the relationship …

Tracers for fluorescence-guided surgery: how elongation of the polymethine chain in cyanine dyes alters the pharmacokinetics of a dual-modality c [RGDyK] tracer

T Buckle, DM van Willigen, SJ Spa… - Journal of Nuclear …, 2018 - Soc Nuclear Med
The potential of receptor-mediated fluorescence-based image-guided surgery tracers is
generally linked to the near-infrared emission profile and good-manufacturing-production …

Smart biomimetic nanozymes for precise molecular imaging: application and challenges

Q Luo, N Shao, AC Zhang, CF Chen, D Wang, LP Luo… - Pharmaceuticals, 2023 - mdpi.com
New nanotechnologies for imaging molecules are widely being applied to visualize the
expression of specific molecules (eg, ions, biomarkers) for disease diagnosis. Among …