The genetic material of all organisms is susceptible to modification. In some instances, these
changes are programmed, such as the formation of DNA double strand breaks during …

Werner syndrome (WS) is a prototypical segmental progeroid syndrome characterized by
multiple features consistent with accelerated aging. It is caused by null mutations of the …

Helicases have major roles in genome maintenance by unwinding structured nucleic acids.
Their prominence is marked by various cancers and genetic disorders that are linked to …

Poly (ADP-ribose)(PAR) and the PAR polymerases (PARPs) that catalyze its synthesis from
donor nicotinamide adenine dinucleotide (NAD+) molecules have received considerable …

Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) and PARP-2 belong to a family of
enzymes that, using NAD+ as a substrate, catalyze poly (ADP-ribosyl) ation of proteins …

Genomic instability leads to mutations, cellular dysfunction and aberrant phenotypes at the
tissue and organism levels. A number of mechanisms have evolved to cope with …

The polyADP‐ribosylation reaction results in a unique post‐translational modification
involved in various cellular processes and conditions, including DNA repair, transcriptional …

Aging is a multifactorial process that depends on diverse molecular and cellular
mechanisms, such as genome maintenance and inflammation. The nuclear enzyme poly …

Aging, the universal phenomenon, affects human health and is the primary risk factor for
major disease pathologies. Progeroid diseases, which mimic aging at an accelerated rate …

Werner's syndrome (WS) is an inherited disease characterized by genomic instability and
premature aging. The WS gene encodes a protein (WRN) with helicase and exonuclease …