This review describes the structure of telomeres, the protective DNA-protein complexes at
eukaryotic chromosomal ends, and several molecular mechanisms involved in telomere …

Telomere length has frequently been used as a means to predict the future life of cells. But
by itself it can be a poor indicator of ageing or cell viability. What, then, is the important …

The telomere end-protection problem is defined by the aggregate of DNA damage signaling
and repair pathways that require repression at telomeres. To define the end-protection …

The SIR genes are determinants of life span in yeast mother cells. Here we show that life
span regulation by the Sir proteins is independent of their role in nonhomologous end …

Ku is an abundant, highly conserved DNA binding protein found in both prokaryotes and
eukaryotes that plays essential roles in the maintenance of genome integrity. In eukaryotes …

The mechanisms that maintain the stability of chromosome ends have broad impact on
genome integrity in all eukaryotes. Budding yeast is a premier organism for telomere …

Telomeres with G-rich repetitive DNA and particular proteins as special heterochromatin
structures at the termini of eukaryotic chromosomes are tightly maintained to safeguard …

Telomeres allow cells to distinguish natural chromosome ends from damaged DNA. When
telomere function is disrupted, a potentially lethal DNA damage response can ensue, DNA …

Saccharomyces cells suffering a single unrepairable double-strand break (DSB) exhibit a
long, but transient arrest at G2/M. hdf1 cells, lacking Ku70p, fail to escape from this …

▪ Abstract Telomeres are essential for genome stability in all eukaryotes. Changes in
telomere functions and the associated chromosomal abnormalities have been implicated in …