The with no lysine (K)(WNK) kinases are an evolutionarily ancient group of kinases with
atypical placement of the catalytic lysine and diverse physiological roles. Recent studies …

Optimum protein function and biochemical activity critically depends on water availability
because solvent thermodynamics drive protein folding and macromolecular interactions …

The Na+-Cl− cotransporter (NCC; SLC12A3) is a highly regulated integral membrane
protein that is known to exist as three splice variants in primates. Its primary role in the …

Abstract Between 6–20% of the cellular proteome is under circadian control and tunes
mammalian cell function with daily environmental cycles. For cell viability, and to maintain …

With no lysine (K)(WNK) kinases regulate epithelial ion transport in the kidney to maintain
homeostasis of electrolyte concentrations and blood pressure. Chloride ion directly binds …

Ammonia is a ubiquitous, toxic by-product of cell metabolism. Its high membrane
permeability and proton affinity cause ammonia to accumulate inside acidic lysosomes in its …

Maintaining internal osmolality constancy is essential for life. Release of arginine
vasopressin (AVP) in response to hyperosmolality is critical. Current hypotheses for …

With No Lysine (K) WNK kinases regulate electro-neutral cotransporters that are controlled
by osmotic stress and chloride. We showed previously that autophosphorylation of WNK1 is …

Cation-coupled chloride cotransporters (CCC) play a role in modulating intracellular
chloride concentration ([Cl−] i) and cell volume. Cell shrinkage and cell swelling are …

The WNK [with no lysine (K)] kinases and their downstream effector kinases, oxidative stress
responsive 1 (OSR1) and SPS/STE20-related proline-alanine–rich kinase (SPAK), have well …