The physics of cancer: the role of physical interactions and mechanical forces in metastasis
Metastasis is a complex, multistep process responsible for> 90% of cancer-related deaths. In
addition to genetic and external environmental factors, the physical interactions of cancer …
addition to genetic and external environmental factors, the physical interactions of cancer …
Adherens junction: the ensemble of specialized cadherin clusters
SM Troyanovsky - Trends in cell biology, 2023 - cell.com
The cell–cell connections in adherens junctions (AJs) are mediated by transmembrane
receptors, type I cadherins (referred to here as cadherins). These cadherin-based …
receptors, type I cadherins (referred to here as cadherins). These cadherin-based …
Genome remodelling in a basal-like breast cancer metastasis and xenograft
Massively parallel DNA sequencing technologies provide an unprecedented ability to
screen entire genomes for genetic changes associated with tumour progression. Here we …
screen entire genomes for genetic changes associated with tumour progression. Here we …
Differential requirement for the dual functions of β-catenin in embryonic stem cell self-renewal and germ layer formation
N Lyashenko, M Winter, D Migliorini, T Biechele… - Nature cell …, 2011 - nature.com
Canonical Wnt signalling has been implicated in mouse and human embryonic stem cell
(ESC) maintenance; however, its requirement is controversial. β-catenin is the key …
(ESC) maintenance; however, its requirement is controversial. β-catenin is the key …
Strength dependence of cadherin-mediated adhesions
Traction forces between adhesive cells play an important role in a number of collective cell
processes. Intercellular contacts, in particular cadherin-based intercellular junctions, are the …
processes. Intercellular contacts, in particular cadherin-based intercellular junctions, are the …
Mapping the dynamics of force transduction at cell–cell junctions of epithelial clusters
Force transduction at cell-cell adhesions regulates tissue development, maintenance and
adaptation. We developed computational and experimental approaches to quantify, with …
adaptation. We developed computational and experimental approaches to quantify, with …
Loss of Setd2 promotes Kras-induced acinar-to-ductal metaplasia and epithelia–mesenchymal transition during pancreatic carcinogenesis
Objective SETD2, the sole histone H3K36 trimethyltransferase, is frequently mutated or
deleted in human cancer, including pancreatic ductal adenocarcinoma (PDAC). However …
deleted in human cancer, including pancreatic ductal adenocarcinoma (PDAC). However …
Mismatch in mechanical and adhesive properties induces pulsating cancer cell migration in epithelial monolayer
The mechanical and adhesive properties of cancer cells significantly change during tumor
progression. Here we assess the functional consequences of mismatched stiffness and …
progression. Here we assess the functional consequences of mismatched stiffness and …
Fracture in living tissues
During development and in adult physiology, living tissues are continuously subjected to
mechanical stresses originating either from cellular processes intrinsic to the tissue or from …
mechanical stresses originating either from cellular processes intrinsic to the tissue or from …
Predicting how cells spread and migrate: focal adhesion size does matter
Efficient cell migration is central to the normal development of tissues and organs and is
involved in a wide range of human diseases, including cancer metastasis, immune …
involved in a wide range of human diseases, including cancer metastasis, immune …