Since the introduction of calcium imaging to monitor neuronal activity with single-cell
resolution, optical imaging methods have revolutionized neuroscience by enabling …

Fluorescence imaging offers expanding capabilities for recording neural dynamics in
behaving mammals, including the means to monitor hundreds of cells targeted by genetic …

Genetically encoded voltage indicators (GEVIs) are a promising technology for fluorescence
readout of millisecond-scale neuronal dynamics. Previous GEVIs had insufficient signaling …

A major technological goal in neuroscience is to enable the interrogation of individual cells
across the live brain. By creating a curved glass replacement to the dorsal cranium and …

From its inception holography has proven an extremely productive and attractive area of
research. While specific technical applications give rise to 'hot topics', and three-dimensional …

Understanding the brain requires a broad range of approaches and methods from the
domains of biology, psychology, chemistry, physics, and mathematics. The fundamental …

Historical milestones in neuroscience have come in diverse forms, ranging from the
resolution of specific biological mysteries via creative experimentation to broad …

Progress in modern neuroscience critically depends on our ability to observe the activity of
large neuronal populations with cellular spatial and high temporal resolution. However, two …

Brain function relies on electrical signaling among ensembles of neurons. These signals are
encoded in space–neurons are organized in complex three-dimensional networks–and in …

Many circuits in the mammalian brain are organized in a topographic or columnar manner.
These circuits could be activated—in ways that reveal circuit function or restore function after …