Oxidative stress, which results in the damage of diverse biological molecules, is a ubiquitous
cellular process implicated in the etiology of many illnesses. The sulfhydryl-containing …

N-acetylcysteine (NAC) is recognized for its role in acetaminophen overdose and as a
mucolytic. Over the past decade, there has been growing evidence for the use of NAC in …

Acetaminophen (APAP) overdose can cause hepatotoxicity and even liver failure. N-
acetylcysteine (NAC) is still the only FDA-approved antidote against APAP overdose 40 …

Aims: N-Acetylcysteine (NAC) is used as an antidote in acetaminophen (APAP) overdose to
prevent and mitigate drug-induced liver injury (DILI). Our objective was to systematically …

Acetylcysteine has been utilized successfully in the treatment of acetaminophen overdose
since the 1970s. Although prospective trials as to efficacy and safety of acetylcysteine were …

Paracetamol (acetaminophen) is an effective oral analgesic, with few adverse effects when
used at the recommended dose. Nevertheless, paracetamol poisoning is common and …

While the traditional intravenous N-acetylcysteine (NAC) dosing regimen works well for the
vast majority of acetaminophen overdoses, there may be cases of massive overdose where …

Introduction: There are few reports summarizing the effectiveness of oral and intravenous
(IV) acetylcysteine. We determined the proportion of acetaminophen poisoned patients who …

Abstract Background. The Extracorporeal Treatments in Poisoning (EXTRIP) workgroup was
created to provide evidence-based recommendations on the use of extracorporeal …

Purpose Appropriate therapies for commonly encountered poisonings, medication
overdoses, and other toxicological emergencies are reviewed, with discussion of …