Reactive oxygen species as mediators of sperm capacitation and pathological damage

RJ Aitken - Molecular reproduction and development, 2017 - Wiley Online Library
Oxidative stress plays a major role in the life and death of mammalian spermatozoa. These
gametes are professional generators of reactive oxygen species (ROS), which appear to …

The importance of oxidative stress in determining the functionality of mammalian spermatozoa: a two-edged sword

RJ Aitken, JR Drevet - Antioxidants, 2020 - mdpi.com
This article addresses the importance of oxidative processes in both the generation of
functional gametes and the aetiology of defective sperm function. Functionally, sperm …

Sperm oxidative stress during in vitro manipulation and its effects on sperm function and embryo development

R Gualtieri, G Kalthur, V Barbato, S Longobardi… - Antioxidants, 2021 - mdpi.com
Reactive oxygen species (ROS) generated at low levels during mitochondrial respiration
have key roles in several signaling pathways. Oxidative stress (OS) arises when the …

The effects of diabetes on male fertility and epigenetic regulation during spermatogenesis

GL Ding, Y Liu, ME Liu, JX Pan, MX Guo… - Asian journal of …, 2015 - journals.lww.com
The effects of diabetes mellitus include long-term damages, dysfunctions, and failures of
various organs. An important complication of diabetes is the disturbance in the male …

Redox Regulation and Oxidative Stress in Mammalian Oocytes and Embryos Developed In Vivo and In Vitro

MLM Hardy, ML Day, MB Morris - International Journal of Environmental …, 2021 - mdpi.com
Oocytes and preimplantation embryos require careful regulation of the redox environment
for optimal development both in vivo and in vitro. Reactive oxygen species (ROS) are …

Insight into oxidative stress in varicocele-associated male infertility: part 1

A Agarwal, A Hamada, SC Esteves - Nature Reviews Urology, 2012 - nature.com
Varicocele is recognized as the leading cause of male infertility because it can impair
spermatogenesis through several distinct pathophysiological mechanisms. Current …

Oxidative stress and reproductive function: The impact of oxidative stress on reproduction: A focus on gametogenesis and fertilization

RJ Aitken, EG Bromfield, Z Gibb - Reproduction, 2022 - rep.bioscientifica.com
In brief Many aspects of the reproductive process are impacted by oxidative stress. This
article summarizes the chemical nature of reactive oxygen species and their role in both the …

Free radicals: their beneficial and detrimental effects on sperm function

S Kothari, A Thompson, A Agarwal, SS du Plessis - 2010 - nopr.niscpr.res.in
Free radicals are molecules with one or more unpaired electron (s) commonly found in
seminal plasma. Physiologically, free radicals control sperm maturation, capacitation and …

[HTML][HTML] Semen evaluation: Methodological advancements in sperm quality-specific fertility assessment—A review

BM Tanga, AY Qamar, S Raza, S Bang, X Fang… - Animal …, 2021 - ncbi.nlm.nih.gov
Assessment of male fertility is based on the evaluation of sperm. Semen evaluation
measures various sperm quality parameters as fertility indicators. However, semen …

[HTML][HTML] Reactive oxygen species as an independent marker of male factor infertility

A Agarwal, RK Sharma, KP Nallella, AJ Thomas Jr… - Fertility and sterility, 2006 - Elsevier
OBJECTIVE: To determine the abnormal patterns of reactive oxygen species (ROS)
production in male factor infertility (MFI) patients and to define the ROS reference values in …