Benzylisoquinoline alkaloids (BIAs) are a structurally diverse group of plant specialized
metabolites with a long history of investigation. Although the ecophysiological functions of …

Covering: up to January 2012 The addition of a methyl moiety to a small chemical is a
common transformation in the biosynthesis of natural products across all three domains of …

Plant cytochromes P450 (P450s) catalyze a wide variety of monooxygenation/hydroxylation
reactions in primary and secondary metabolism. The number of P450 genes in plant …

The benzylisoquinoline alkaloids (BIAs) are a diverse class of metabolites that exhibit a
broad range of pharmacological activities and are synthesized through plant biosynthetic …

When we edited in 2007 the first issue on transient receptor potential channel in the
Handbook of Experimental Pharmacology, we were all very excited by the progress in this …

Biological oxidations form the basis of life on earth by utilizing organic compounds as
electron donors to drive the generation of metabolic energy carriers, such as ATP. Oxidative …

Numerous drugs and drug precursors in the current pharmacopoeia originate from plant
sources. The limited yield of some bioactive compounds in plant tissues, however, presents …

Covering: up to February 2009Plants produce an estimated 200,000 secondary metabolites
with a vast range of functional and structural diversity. This chemical diversity is due to the …

Since ancient times, opium poppy (Papaver somniferum L.) is known for its medicinal
properties, related to its secondary metabolite content. Its most important secondary …

Lotus predominantly accumulates benzylisoquinoline alkaloids (BIAs), but their biosynthesis
and regulation remain unclear. Here, we investigated structural and regulatory genes …