Chronic, pathological pain remains a global health problem and a challenge to basic and
clinical sciences. A major obstacle to preventing, treating, or reverting chronic pain has been …

The prefrontal cortex (PFC) is not only important in executive functions, but also pain
processing. The latter is dependent on its connections to other areas of the cerebral …

Pathological alterations to the locus coeruleus, the major source of noradrenaline in the
brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI …

The locus coeruleus (LC) projects throughout the brain and spinal cord and is the major
source of central noradrenaline. It remains unclear whether the LC acts functionally as a …

Introduction: Given our improved understanding of the role of central sensitization (CS) in
many patients with chronic pain, it seems rational to account for CS during treatment. Areas …

The locus coeruleus (LC)-noradrenergic system is the main source of noradrenaline in the
central nervous system and is involved intensively in modulating pain and stress-related …

Chronic pain often occurs in the elderly, particularly in the patients with neurodegenerative
disorders such as Alzheimer's disease (AD). Although studies indicate that chronic pain …

Preclinical investigations have suggested that altered functioning of brainstem pain-
modulation circuits may be crucial for the maintenance of some chronic pain conditions …

There is strong comorbidity between chronic pain and depression, although the neural
circuits and mechanisms underlying this association remain unclear. By combining …

Alzheimer's disease (AD) is a progressive and deleterious neurodegenerative disease,
strongly affecting the cognitive functions and memory of seniors worldwide. Around 58% of …