Lipoxygenases (LOXs) catalyze the oxidation of polyunsaturated fatty acids and synthesize
oxylipin products that drive important cellular signaling processes in plants and animals …

Lipoxygenases (LOXs) biosynthesize lipid mediators (LMs) as human signaling molecules.
Among LMs, specialized pro-resolving mediators (SPMs) are involved in the resolution of …

Abstract Leukotrienes (LTs) and maresins (MaRs) are human lipid mediators (LMs) involved
in immune response and anti‐inflammation, respectively. These compounds and their …

Lipoxygenases (LOXs) catalyze the dioxygenation of PUFAs to produce regio-and
stereospecific oxygenated fatty acids. The identification of regio-and stereospecific LOXs is …

Objective To quantitatively hydroxylate 8 S-and 10 S-positions on polyunsaturated fatty
acids by recombinant Escherichia coli cells expressing mouse arachidonate 8 S …

Eicosanoids are critical mediators of fever, pain, and inflammation generated by immune
and tissue cells. We recently described a new bioactive eicosanoid generated by …

This Chapter describes methods for the biosynthetic substitution of the mononuclear, non-
heme iron in plant and animal lipoxygenases (LOXs). Substitution of this iron center for a …

Catalase-related allene oxide synthase (cAOS) is a hemoprotein that converts a specific fatty
acid hydroperoxide to an unstable allene oxide intermediate at turnover rates in the order of …

The primary substrate for animal lipoxygenases is arachidonic acid, and the oxygenated
products of these fatty acids are classified as eicosanoids. Eicosanoids are potent signaling …