Carotenoid metabolism at the intestinal barrier
J von Lintig, J Moon, J Lee, S Ramkumar - Biochimica et Biophysica Acta …, 2020 - Elsevier
Carotenoids exert a rich variety of physiological functions in mammals and are beneficial for
human health. These lipids are acquired from the diet and metabolized to apocarotenoids …
human health. These lipids are acquired from the diet and metabolized to apocarotenoids …
Biochemical and physiological importance of the CYP26 retinoic acid hydroxylases
N Isoherranen, G Zhong - Pharmacology & therapeutics, 2019 - Elsevier
Abstract The Cytochrome P450 (CYP) family 26 enzymes contribute to retinoic acid (RA)
metabolism and homeostasis in humans, mammals and other chordates. The three CYP26 …
metabolism and homeostasis in humans, mammals and other chordates. The three CYP26 …
Molecular components affecting ocular carotenoid and retinoid homeostasis
J von Lintig, J Moon, D Babino - Progress in retinal and eye research, 2021 - Elsevier
The photochemistry of vision employs opsins and geometric isomerization of their covalently
bound retinylidine chromophores. In different animal classes, these light receptors associate …
bound retinylidine chromophores. In different animal classes, these light receptors associate …
Variants in ALDH1A2 reveal an anti-inflammatory role for retinoic acid and a new class of disease-modifying drugs in osteoarthritis
More than 40% of individuals will develop osteoarthritis (OA) during their lifetime, yet there
are currently no licensed disease-modifying treatments for this disabling condition. Common …
are currently no licensed disease-modifying treatments for this disabling condition. Common …
Retinoic acid signaling in development and differentiation commitment and its regulatory topology
D Wu, FA Khan, K Zhang, NS Pandupuspitasari… - Chemico-Biological …, 2023 - Elsevier
Retinoic acid (RA), the derivative of vitamin A/retinol, is a signaling molecule with important
implications in health and disease. It is a well-known developmental morphogen that …
implications in health and disease. It is a well-known developmental morphogen that …
Retinoids in the pathogenesis and treatment of liver diseases
Vitamin A (VA), all-trans-retinol (ROL), and its analogs are collectively called retinoids.
Acting through the retinoic acid receptors RARα, RARβ, and RARγ, all-trans-retinoic acid, an …
Acting through the retinoic acid receptors RARα, RARβ, and RARγ, all-trans-retinoic acid, an …
Cyp26a1 supports postnatal retinoic acid homeostasis and glucoregulatory control
Considerable evidence confirms the importance of Cyp26a1 to all-trans-retinoic acid (RA)
homeostasis during embryogenesis. In contrast, despite its presence in postnatal liver as a …
homeostasis during embryogenesis. In contrast, despite its presence in postnatal liver as a …
Temporal changes in the systemic concentrations of retinoids in pregnant and postpartum women
Retinoids and vitamin A are essential for multiple biological functions, including vision and
immune responses, as well as the development of an embryo during pregnancy. Despite its …
immune responses, as well as the development of an embryo during pregnancy. Despite its …
Reduced retinoic acid signaling during gastrulation induces developmental microcephaly
M Gur, L Bendelac-Kapon, Y Shabtai… - Frontiers in Cell and …, 2022 - frontiersin.org
Retinoic acid (RA) is a central signaling molecule regulating multiple developmental
decisions during embryogenesis. Excess RA induces head malformations, primarily by …
decisions during embryogenesis. Excess RA induces head malformations, primarily by …
[HTML][HTML] Knockout of Cyp26a1 and Cyp26b1 during post-natal life causes reduced lifespan, dermatitis, splenomegaly and systemic inflammation in mice
All-trans-retinoic acid (atRA), the active metabolite of vitamin A, is an essential signaling
molecule in all chrodates. Global knockout of the atRA clearing enzymes Cyp26a1 or …
molecule in all chrodates. Global knockout of the atRA clearing enzymes Cyp26a1 or …