[HTML][HTML] Structure-activity-relationship and mechanistic insights for anti-HIV natural products
Acquired Immunodeficiency Syndrome (AIDS), which chiefly originatesfroma retrovirus
named Human Immunodeficiency Virus (HIV), has impacted about 70 million people …
named Human Immunodeficiency Virus (HIV), has impacted about 70 million people …
[HTML][HTML] The neuronal gene arc encodes a repurposed retrotransposon gag protein that mediates intercellular RNA transfer
ED Pastuzyn, CE Day, RB Kearns, M Kyrke-Smith… - Cell, 2018 - cell.com
The neuronal gene Arc is essential for long-lasting information storage in the mammalian
brain, mediates various forms of synaptic plasticity, and has been implicated in …
brain, mediates various forms of synaptic plasticity, and has been implicated in …
[HTML][HTML] Retroviral RNA dimerization: from structure to functions
N Dubois, R Marquet, JC Paillart… - Frontiers in …, 2018 - frontiersin.org
The genome of the retroviruses is a dimer composed by two homologous copies of genomic
RNA (gRNA) molecules of positive polarity. The dimerization process allows two gRNA …
RNA (gRNA) molecules of positive polarity. The dimerization process allows two gRNA …
[HTML][HTML] Nano-DMS-MaP allows isoform-specific RNA structure determination
Genome-wide measurements of RNA structure can be obtained using reagents that react
with unpaired bases, leading to adducts that can be identified by mutational profiling on next …
with unpaired bases, leading to adducts that can be identified by mutational profiling on next …
5′-Cap sequestration is an essential determinant of HIV-1 genome packaging
P Ding, S Kharytonchyk, N Kuo… - Proceedings of the …, 2021 - National Acad Sciences
HIV-1 selectively packages two copies of its 5′-capped RNA genome (gRNA) during virus
assembly, a process mediated by the nucleocapsid (NC) domain of the viral Gag polyprotein …
assembly, a process mediated by the nucleocapsid (NC) domain of the viral Gag polyprotein …
[HTML][HTML] Short-and long-range interactions in the HIV-1 5′ UTR regulate genome dimerization and packaging
RNA dimerization is the noncovalent association of two human immunodeficiency virus-1
(HIV-1) genomes. It is a conserved step in the HIV-1 life cycle and assumed to be a …
(HIV-1) genomes. It is a conserved step in the HIV-1 life cycle and assumed to be a …
Transcriptional start site heterogeneity modulates the structure and function of the HIV-1 genome
The promoter in HIV type 1 (HIV-1) proviral DNA contains three sequential guanosines at the
U3–R boundary that have been proposed to function as sites for transcription initiation. Here …
U3–R boundary that have been proposed to function as sites for transcription initiation. Here …
Epitranscriptomic regulation of HIV-1 full-length RNA packaging
C Pereira-Montecinos, D Toro-Ascuy… - Nucleic Acids …, 2022 - academic.oup.com
During retroviral replication, the full-length RNA serves both as mRNA and genomic RNA.
However, the mechanisms by which the HIV-1 Gag protein selects the two RNA molecules …
However, the mechanisms by which the HIV-1 Gag protein selects the two RNA molecules …
Identification of the initial nucleocapsid recognition element in the HIV-1 RNA packaging signal
P Ding, S Kharytonchyk, A Waller… - Proceedings of the …, 2020 - National Acad Sciences
Selective packaging of the HIV-1 genome during virus assembly is mediated by interactions
between the dimeric 5ʹ-leader of the unspliced viral RNA and the nucleocapsid (NC) …
between the dimeric 5ʹ-leader of the unspliced viral RNA and the nucleocapsid (NC) …
Molecular physiology of Arc/Arg3. 1: The oligomeric state hypothesis of synaptic plasticity
MS Eriksen, CR Bramham - Acta Physiologica, 2022 - Wiley Online Library
The immediate early gene, Arc, is a pivotal regulator of synaptic plasticity, memory, and
cognitive flexibility. But what is Arc protein? How does it work? Inside the neuron, Arc is a …
cognitive flexibility. But what is Arc protein? How does it work? Inside the neuron, Arc is a …