Network pharmacology in research of Chinese medicine formula: methodology, application and prospective
T Luo, Y Lu, S Yan, X Xiao, X Rong, J Guo - Chinese journal of integrative …, 2020 - Springer
Chinese medicine (CM) is usually prescribed as CM formula to treat disease. The lack of
effective research approach makes it difficult to elucidate the molecular mechanisms of CM …
effective research approach makes it difficult to elucidate the molecular mechanisms of CM …
Deep learning algorithms for human activity recognition using mobile and wearable sensor networks: State of the art and research challenges
Human activity recognition systems are developed as part of a framework to enable
continuous monitoring of human behaviours in the area of ambient assisted living, sports …
continuous monitoring of human behaviours in the area of ambient assisted living, sports …
Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response
CN Spencer, JL McQuade, V Gopalakrishnan… - Science, 2021 - science.org
Gut bacteria modulate the response to immune checkpoint blockade (ICB) treatment in
cancer, but the effect of diet and supplements on this interaction is not well studied. We …
cancer, but the effect of diet and supplements on this interaction is not well studied. We …
Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients
Anti–programmed cell death protein 1 (PD-1) therapy provides long-term clinical benefits to
patients with advanced melanoma. The composition of the gut microbiota correlates with anti …
patients with advanced melanoma. The composition of the gut microbiota correlates with anti …
[HTML][HTML] Metascape provides a biologist-oriented resource for the analysis of systems-level datasets
Y Zhou, B Zhou, L Pache, M Chang… - Nature …, 2019 - nature.com
A critical component in the interpretation of systems-level studies is the inference of enriched
biological pathways and protein complexes contained within OMICs datasets. Successful …
biological pathways and protein complexes contained within OMICs datasets. Successful …
[HTML][HTML] A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models
Idiopathic pulmonary fibrosis (IPF) is an aggressive interstitial lung disease with a high
mortality rate. Putative drug targets in IPF have failed to translate into effective therapies at …
mortality rate. Putative drug targets in IPF have failed to translate into effective therapies at …
[HTML][HTML] Integrated omics of metastatic colorectal cancer
We integrate the genomics, proteomics, and phosphoproteomics of 480 clinical tissues from
146 patients in a Chinese colorectal cancer (CRC) cohort, among which 70 had metastatic …
146 patients in a Chinese colorectal cancer (CRC) cohort, among which 70 had metastatic …
[HTML][HTML] Mechanisms underlying the therapeutic effects of Qingfeiyin in treating acute lung injury based on GEO datasets, network pharmacology and molecular …
Y Wang, Y Yuan, W Wang, Y He, H Zhong… - Computers in biology …, 2022 - Elsevier
Background Qingfeiyin (QFY) is a common Chinese herbal formula for the treatment of acute
lung injury (ALI). However, its mechanisms of action are unclear. In this study, we …
lung injury (ALI). However, its mechanisms of action are unclear. In this study, we …
[HTML][HTML] Identification of microbial markers across populations in early detection of colorectal cancer
Associations between gut microbiota and colorectal cancer (CRC) have been widely
investigated. However, the replicable markers for early-stage adenoma diagnosis across …
investigated. However, the replicable markers for early-stage adenoma diagnosis across …
A review on drug repurposing applicable to COVID-19
S Dotolo, A Marabotti, A Facchiano… - Briefings in …, 2021 - academic.oup.com
Drug repurposing involves the identification of new applications for existing drugs at a lower
cost and in a shorter time. There are different computational drug-repurposing strategies and …
cost and in a shorter time. There are different computational drug-repurposing strategies and …