Principles of odor coding in vertebrates and artificial chemosensory systems
I Manzini, D Schild, C Di Natale - Physiological reviews, 2022 - journals.physiology.org
The biological olfactory system is the sensory system responsible for the detection of the
chemical composition of the environment. Several attempts to mimic biological olfactory …
chemical composition of the environment. Several attempts to mimic biological olfactory …
Microfluidics for neuronal cell and circuit engineering
The widespread adoption of microfluidic devices among the neuroscience and neurobiology
communities has enabled addressing a broad range of questions at the molecular, cellular …
communities has enabled addressing a broad range of questions at the molecular, cellular …
[HTML][HTML] Changes in genome architecture and transcriptional dynamics progress independently of sensory experience during post-natal brain development
Both transcription and three-dimensional (3D) architecture of the mammalian genome play
critical roles in neurodevelopment and its disorders. However, 3D genome structures of …
critical roles in neurodevelopment and its disorders. However, 3D genome structures of …
LHX2-and LDB1-mediated trans interactions regulate olfactory receptor choice
The genome is partitioned into topologically associated domains and genomic
compartments with shared chromatin valence. This architecture is constrained by the DNA …
compartments with shared chromatin valence. This architecture is constrained by the DNA …
[HTML][HTML] RNA-mediated symmetry breaking enables singular olfactory receptor choice
Olfactory receptor (OR) choice provides an extreme example of allelic competition for
transcriptional dominance, where every olfactory neuron stably transcribes one of …
transcriptional dominance, where every olfactory neuron stably transcribes one of …
[HTML][HTML] Deconstructing olfactory stem cell trajectories at single-cell resolution
A detailed understanding of the paths that stem cells traverse to generate mature progeny is
vital for elucidating the mechanisms governing cell fate decisions and tissue homeostasis …
vital for elucidating the mechanisms governing cell fate decisions and tissue homeostasis …
scMerge leverages factor analysis, stable expression, and pseudoreplication to merge multiple single-cell RNA-seq datasets
Concerted examination of multiple collections of single-cell RNA sequencing (RNA-seq)
data promises further biological insights that cannot be uncovered with individual datasets …
data promises further biological insights that cannot be uncovered with individual datasets …
Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly
The vertebrate clustered protocadherin (Pcdh) cell surface proteins are encoded by three
closely linked gene clusters (Pcdh α, Pcdh β, and Pcdh γ). Here, we show that all three gene …
closely linked gene clusters (Pcdh α, Pcdh β, and Pcdh γ). Here, we show that all three gene …
[HTML][HTML] Simultaneous single-cell three-dimensional genome and gene expression profiling uncovers dynamic enhancer connectivity underlying olfactory receptor …
The simultaneous measurement of three-dimensional (3D) genome structure and gene
expression of individual cells is critical for understanding a genome's structure–function …
expression of individual cells is critical for understanding a genome's structure–function …
[HTML][HTML] Odor coding in the mammalian olfactory epithelium
Noses are extremely sophisticated chemical detectors allowing animals to use scents to
interpret and navigate their environments. Odor detection starts with the activation of odorant …
interpret and navigate their environments. Odor detection starts with the activation of odorant …