Engineering a model cell for rational tuning of GPCR signaling
WM Shaw, H Yamauchi, J Mead, GOF Gowers, DJ Bell… - Cell, 2019 - cell.com
G protein-coupled receptor (GPCR) signaling is the primary method eukaryotes use to
respond to specific cues in their environment. However, the relationship between stimulus …
respond to specific cues in their environment. However, the relationship between stimulus …
Transmembrane signaling in Saccharomyces cerevisiae as a model for signaling in metazoans: state of the art after 25 years
D Engelberg, R Perlman, A Levitzki - Cellular signalling, 2014 - Elsevier
In the very first article that appeared in Cellular Signalling, published in its inaugural issue in
October 1989, we reviewed signal transduction pathways in Saccharomyces cerevisiae …
October 1989, we reviewed signal transduction pathways in Saccharomyces cerevisiae …
Specific α-Arrestins Negatively Regulate Saccharomyces cerevisiae Pheromone Response by Down-Modulating the G-Protein-Coupled Receptor Ste2
CG Alvaro, AF O'Donnell, DC Prosser… - … and Cellular Biology, 2014 - Taylor & Francis
G-protein-coupled receptors (GPCRs) are integral membrane proteins that initiate
responses to extracellular stimuli by mediating ligand-dependent activation of cognate …
responses to extracellular stimuli by mediating ligand-dependent activation of cognate …
Metabolic and chaperone gene loss marks the origin of animals: evidence for Hsp104 and Hsp78 chaperones sharing mitochondrial enzymes as clients
AJ Erives, JS Fassler - PloS one, 2015 - journals.plos.org
The evolution of animals involved acquisition of an emergent gene repertoire for
gastrulation. Whether loss of genes also co-evolved with this developmental reprogramming …
gastrulation. Whether loss of genes also co-evolved with this developmental reprogramming …
Reshaping the yeast galactose regulon via GPCR signaling cascade
C Fan, J Yuan - Cell Reports Methods, 2023 - cell.com
Dynamically regulated systems are preferable to control metabolic pathways for an
improved strain performance with better productivity. Here, we harnessed to the G protein …
improved strain performance with better productivity. Here, we harnessed to the G protein …
Sensory input attenuation allows predictive sexual response in yeast
Animals are known to adjust their sexual behaviour depending on mate competition. Here
we report similar regulation for mating behaviour in a sexual unicellular eukaryote, the …
we report similar regulation for mating behaviour in a sexual unicellular eukaryote, the …
Deterministic mathematical models of the cAMP pathway in Saccharomyces cerevisiae
T Williamson, JM Schwartz, DB Kell, L Stateva - BMC systems biology, 2009 - Springer
Background Cyclic adenosine monophosphate (cAMP) has a key signaling role in all
eukaryotic organisms. In Saccharomyces cerevisiae, it is the second messenger in the …
eukaryotic organisms. In Saccharomyces cerevisiae, it is the second messenger in the …
Variable dependence of signaling output on agonist occupancy of Ste2p, a G protein-coupled receptor in yeast
R Sridharan, SM Connelly, F Naider… - Journal of Biological …, 2016 - ASBMB
We report here on the relationship between ligand binding and signaling responses in the
yeast pheromone response pathway, a well characterized G protein-coupled receptor …
yeast pheromone response pathway, a well characterized G protein-coupled receptor …
Фундаментальные и прикладные аспекты использования системной биологии
МЮ Чередниченко, АС Доброногова… - … и технические науки, 2020 - elibrary.ru
Рассмотрена концепция системной биологии, а также ее приложение в сфере
фундаментальных исследований, медицины, фармацевтики, сельского хозяйства …
фундаментальных исследований, медицины, фармацевтики, сельского хозяйства …