G protein-coupled receptor (GPCR) signaling is the primary method eukaryotes use to
respond to specific cues in their environment. However, the relationship between stimulus …

In the very first article that appeared in Cellular Signalling, published in its inaugural issue in
October 1989, we reviewed signal transduction pathways in Saccharomyces cerevisiae …

G-protein-coupled receptors (GPCRs) are integral membrane proteins that initiate
responses to extracellular stimuli by mediating ligand-dependent activation of cognate …

The evolution of animals involved acquisition of an emergent gene repertoire for
gastrulation. Whether loss of genes also co-evolved with this developmental reprogramming …

Dynamically regulated systems are preferable to control metabolic pathways for an
improved strain performance with better productivity. Here, we harnessed to the G protein …

Animals are known to adjust their sexual behaviour depending on mate competition. Here
we report similar regulation for mating behaviour in a sexual unicellular eukaryote, the …

Background Cyclic adenosine monophosphate (cAMP) has a key signaling role in all
eukaryotic organisms. In Saccharomyces cerevisiae, it is the second messenger in the …

We report here on the relationship between ligand binding and signaling responses in the
yeast pheromone response pathway, a well characterized G protein-coupled receptor …

Рассмотрена концепция системной биологии, а также ее приложение в сфере
фундаментальных исследований, медицины, фармацевтики, сельского хозяйства …

In the mid 1990s when Leroy Hood reintroduced the term “Systems Biology”, the fusion of
ideas gave rise to confusion to such an extent that there used to be special talks on 'what is …