The concentration of Ca 2+ in the endoplasmic reticulum (ER) is critically important for
maintaining its oxidizing environment as well as for maintaining luminal ATP levels required …

The membrane of the endoplasmic reticulum (ER) of nucleated human cells harbors the
protein translocon, which facilitates membrane integration or translocation of almost every …

The heterotrimeric Sec61 complex and the dimeric Sec62/Sec63 complex are located in the
membrane of the human endoplasmic reticulum (ER) and play a central role in translocation …

Autosomal-dominant tubulo-interstitial kidney disease (ADTKD) encompasses a group of
disorders characterized by renal tubular and interstitial abnormalities, leading to slow …

The Sec61 complex forms a protein-conducting channel in the endoplasmic reticulum
membrane that is required for secretion of soluble proteins and production of many …

Members of the evolutionarily conserved Oxa1/Alb3/YidC family mediate membrane protein
biogenesis at the mitochondrial inner membrane, chloroplast thylakoid membrane, and …

In mammalian cells, signal peptide‐dependent protein transport into the endoplasmic
reticulum (ER) is mediated by a dynamic protein‐conducting channel, the Sec61 complex …

Co-translational transport of polypeptides into the endoplasmic reticulum (ER) involves the
Sec61 channel and additional components such as the ER lumenal Hsp70 BiP and its …

Most intracellular Ca2+ signals result from opening of Ca2+ channels in the plasma
membrane or endoplasmic reticulum (ER), and they are reversed by active transport across …

The rough endoplasmic reticulum (ER) of nucleated human cells has crucial functions in
protein biogenesis, calcium (Ca2+) homeostasis, and signal transduction. Among the …