The P2X7 receptor: a main player in inflammation
Damage associated molecular patterns (DAMPs) are intracellular molecules released from
infected or injured cells to activate inflammatory and reparatory responses. One of the most …
infected or injured cells to activate inflammatory and reparatory responses. One of the most …
The P2X7 receptor: central hub of brain diseases
R Andrejew, Á Oliveira-Giacomelli… - Frontiers in Molecular …, 2020 - frontiersin.org
The P2X7 receptor is a cation channel activated by high concentrations of adenosine
triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming …
triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming …
Astrocytes as guardians of neuronal excitability: mechanisms underlying epileptogenesis
QP Verhoog, L Holtman, E Aronica… - Frontiers in …, 2020 - frontiersin.org
Astrocytes are key homeostatic regulators in the central nervous system and play important
roles in physiology. After brain damage caused by eg, status epilepticus, traumatic brain …
roles in physiology. After brain damage caused by eg, status epilepticus, traumatic brain …
Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder
K Recourt, P de Boer, P van der Ark, H Benes… - Translational …, 2023 - nature.com
JNJ-54175446 is a selective purine P2X7 receptor (P2X7R) antagonist that attenuates
microglial IL-1β/IL-18 release. In healthy volunteers, JNJ-54175446 suppressed peripheral …
microglial IL-1β/IL-18 release. In healthy volunteers, JNJ-54175446 suppressed peripheral …
Medicinal chemistry of adenosine, P2Y and P2X receptors
KA Jacobson, CE Müller - Neuropharmacology, 2016 - Elsevier
Pharmacological tool compounds are now available to define action at the adenosine (ARs),
P2Y and P2X receptors. We present a selection of the most commonly used agents to study …
P2Y and P2X receptors. We present a selection of the most commonly used agents to study …
P2X7 in cancer: from molecular mechanisms to therapeutics
R Lara, E Adinolfi, CA Harwood, M Philpott… - Frontiers in …, 2020 - frontiersin.org
P2X7 is a transmembrane receptor expressed in multiple cell types including neurons,
dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of …
dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of …
The microglial ATP‐gated ion channel P2X7 as a CNS drug target
A Bhattacharya, K Biber - Glia, 2016 - Wiley Online Library
Based on promising preclinical evidence, microglial P2X7 has increasingly being
recognized as a target for therapeutic intervention in neurological and psychiatric diseases …
recognized as a target for therapeutic intervention in neurological and psychiatric diseases …
Involvement of P2X7 receptors in chronic pain disorders
WJ Ren, P Illes - Purinergic Signalling, 2022 - Springer
Chronic pain is caused by cellular damage with an obligatory inflammatory component. In
response to noxious stimuli, high levels of ATP leave according to their concentration …
response to noxious stimuli, high levels of ATP leave according to their concentration …
Discovery of potent cholinesterase inhibition-based multi-target-directed lead compounds for synaptoprotection in Alzheimer's disease
Drug development efforts that focused on single targets failed to provide effective treatment
for Alzheimer's disease (AD). Therefore, we designed cholinesterase inhibition (ChEI) …
for Alzheimer's disease (AD). Therefore, we designed cholinesterase inhibition (ChEI) …
Purinergic mechanisms in neuroinflammation: an update from molecules to behavior
E Beamer, F Gölöncsér, G Horváth, K Bekő… - …, 2016 - Elsevier
The principle functions of neuroinflammation are to limit tissue damage and promote tissue
repair in response to pathogens or injury. While neuroinflammation has utility …
repair in response to pathogens or injury. While neuroinflammation has utility …