β-thalassemia is a disease caused by genetic mutations including a nucleotide change,
small insertions or deletions in the β-globin gene, or in rare cases, gross deletions into the β …

Apoptosis is a process of programmed cell death which has an important role in tissue
homeostasis and in the control of organism development. Here, we focus on information …

In Guangxi, Hainan, and Fujian Province in southern China, β-thalassemia is a frequent
monogenic hereditary disorder that is primarily defined by hemolytic anemia brought on by …

Defective hemoglobin production and ineffective erythropoiesis contribute to the
pathophysiology of thalassemia syndromes. Previous studies in the field of erythropoiesis …

Red blood cell production is negatively controlled by the rate of apoptosis at the stage of
CFU-E/pro-erythroblast differentiation, depending on the balance between erythropoietin …

Abstract Exportin-1 (XPO1), also known as chromosome region maintenance 1 (CRM1),
directly binds to and mediates the nuclear export of hundreds of cargo proteins. Blocking …

Background Primary mediastinal B-cell lymphoma (PMBL) and classical Hodgkin lymphoma
(cHL) are distinct hematological malignancies of B-cell origin that share many biological …

Red blood cell production, or erythropoiesis, is a proliferative process that requires tight
regulation. Erythropoietin (Epo) is a glycoprotein cytokine that plays a major role in …

Apoptosis plays an important role in ineffective erythropoiesis in β-thalassemia. This early
destruction causes severe anemia and contributes significantly to patient mortality. There …

Objective Transfusion of HLA-matched platelets can reduce the effect of alloimmune
responses on platelet transfusion efficacy; however, finding HLA-matched platelets in the …