Patterns of replication within eukaryotic genomes correlate with gene expression, chromatin
structure, and genome evolution. Recent advances in genome-scale mapping of replication …

Cell-cycle transitions in higher eukaryotes are regulated by different cyclin-dependent
kinases (CDKs) and their activating cyclin subunits. Based on pioneering findings that a …

Cell cycle transitions result from global changes in protein phosphorylation states triggered
by cyclin-dependent kinases (CDKs). To understand how this complexity produces an …

DNA replication is central to cell proliferation. Studies in the past six decades since the
proposal of a semiconservative mode of DNA replication have confirmed the high degree of …

At each cell division in humans, 30,000–50,000 DNA replication origins are activated, and it
remains unclear how they are selected and recognized by replication factors. DNA …

Replication origins are licensed by loading MCM2-7 hexamers before entry into S phase.
However, only∼ 10% of licensed origins are normally used in S phase, with the others …

DNA replication in eukaryotic cells initiates from multiple replication origins that are
distributed throughout the genome. Coordinating the usage of these origins is crucial to …

DNA replication initiates from multiple genomic locations called replication origins. In
metazoa, DNA sequence elements involved in origin specification remain elusive. Here, we …

Fifteen years ago, it was proposed that the cell cycle in fission yeast can be driven by
quantitative changes in the activity of a single protein kinase complex comprising a cyclin …

The mitosis-to-endocycle transition requires the controlled inactivation of M phase-
associated cyclin-dependent kinase (CDK) activity. Previously, the B-type CDKB1; 1 was …