Allostasis, or stability through change, has most often been linked with challenges to
homeostasis, in which repeated challenges or stressors produce sufficient allostatic load to …

Stress has long been suggested to be an important correlate of uncontrolled drinking and
relapse. An important hormonal response system to stress—the hypothalamic–pituitary …

Alcohol consumption has been linked to over 200 diseases and is responsible for over 5%
of the global disease burden. Well-known genetic variants in alcohol metabolizing genes, for …

Melatonin production is highly conserved in nature through different species including
bacteria, unicellular eukaryotes, algae, plants invertebrates, and vertebrates (Hardeland et …

Scholarly and comprehensive yet accessible, this state-of-the-science work is widely
regarded as the definitive graduate-level psychology of religion text. The authors synthesize …

Compulsive drug seeking that is associated with addiction is hypothesized to follow a
heuristic framework that involves three stages (binge/intoxication, withdrawal/negative affect …

Rationale Genetic and environmental influences on the development of alcohol and drug
dependence are equally important. Exposure to early life stress, that is unfortunately …

The discovery of corticotropin-releasing factor (CRF) or CRH defining the upper regulatory
arm of the hypothalamic-pituitary-adrenal (HPA) axis, along with the identification of the …

Stress is commonly regarded as an important trigger for relapse and a significant factor that
promotes increased motivation to drink in some individuals. However, the relationship …

A concatenation of findings from preclinical and clinical studies support a preeminent
function for the corticotropin-releasing factor (CRF) system in mediating the physiological …