Simple Summary Accumulating evidence indicates that hypoxia-inducible factor-1 (HIF-1)
plays a pivotal role in tumor biology, particularly in hypoxic environments. Over the past few …

Mitochondria are essential cellular organelles that are involved in regulating cellular energy,
metabolism, survival, and proliferation. To some extent, cancer is a genetic and metabolic …

Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second deadliest
cancer by 2030, and the overall 5-year survival rate is currently less than 7%. Cancer cells …

The use of repurposing drugs that may have neoplastic and anticancer effects increases the
efficiency and decrease resistance to chemotherapy drugs through a biochemical and …

Background To identify potential targets related to nicotinamide adenine dinucleotide
(NAD+) metabolism in gliomas, we used RNA immunoprecipitation to identify a novel long …

High-dose dexamethasone (DEX) is used to treat chemotherapy-induced nausea and
vomiting or to control immunotherapy-related autoimmune diseases in clinical practice …

Reliable and noninvasive biomarkers for the early diagnosis of non‐small‐cell lung cancer
(NSCLC) are an unmet need. This study aimed to screen and validate potential urinary …

AC1497 is an effective dual inhibitor of malate dehydrogenase 1 and 2 targeting cancer
metabolism. However, its poor aqueous solubility results in low bioavailability, limiting its …

Abstract Hypoxia-inducible factor (HIF)-1 is an important regulator of the cellular response in
the hypoxic tumor environment. While searching for HIF inhibitors derived from natural …

MDH1 and MDH2 enzymes play an important role in the survival of lung cancer. In this
study, a novel series of dual MDH1/2 inhibitors for lung cancer was rationally designed and …