Computer-aided drug discovery/design methods have played a major role in the
development of therapeutically important small molecules for over three decades. These …

There is a high degree of overlap between brain regions involved in processing natural
rewards and drugs of abuse.“Non-drug” or “behavioral” addictions have become …

Sensation-seeking (SS) is a personality trait that refers to individual differences in motivation
for intense and unusual sensory experiences. It describes a facet of human behaviour that …

Introduction Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental
disorder affecting up to 5.3% of children and 2.5% of adults depending on the country …

Attention‐deficit hyperactivity disorder (ADHD) is the most common psychiatric disorder in
children and adolescents, which is characterized by behavioral problems such as attention …

The glutamatergic neurotransmitter system may play an important role in attention-deficit
hyperactivity disorder (ADHD). This 5-week, open-label, single-blind, placebo-controlled …

We synthesized a mitochondria-targeted honokiol (Mito-HNK) that facilitates its
mitochondrial accumulation; this dramatically increases its potency and efficacy against …

Repeated cocaine exposure causes persistent, maladaptive alterations in brain and
behavior, and hope for effective therapeutics lies in understanding these processes. We …

Gambling disorder (GD), previously called pathological gambling and classified as an
impulse control disorder in DSM‐III and DSM‐IV, has recently been reclassified as an …

This review is an introduction to addiction, the reward circuitry, and laboratory addiction
models. Addiction is a chronic disease hallmarked by a state of compulsive drug seeking …