Cruciferous vegetables and their bioactive metabolites: from prevention to novel therapies of colorectal cancer
The Brassicaceae family, known as cruciferous vegetables, includes many economically
important species, mainly edible oil plants, vegetable species, spice plants, and feed plants …
important species, mainly edible oil plants, vegetable species, spice plants, and feed plants …
Cell cycle proteins as promising targets in cancer therapy
T Otto, P Sicinski - Nature Reviews Cancer, 2017 - nature.com
Cancer is characterized by uncontrolled tumour cell proliferation resulting from aberrant
activity of various cell cycle proteins. Therefore, cell cycle regulators are considered …
activity of various cell cycle proteins. Therefore, cell cycle regulators are considered …
Living with or without cyclins and cyclin-dependent kinases
CJ Sherr, JM Roberts - Genes & development, 2004 - genesdev.cshlp.org
Entry into, progression through, and exit from the G1 phase of the mammalian cell cycle in
response to extracellular mitogenic cues are presumed to be governed by cyclin-dependent …
response to extracellular mitogenic cues are presumed to be governed by cyclin-dependent …
Minireview: Cyclin D1: normal and abnormal functions
M Fu, C Wang, Z Li, T Sakamaki, RG Pestell - Endocrinology, 2004 - academic.oup.com
Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and
inactivates the retinoblastoma protein and promotes progression through the G1-S phase of …
inactivates the retinoblastoma protein and promotes progression through the G1-S phase of …
Signaling through cyclin D-dependent kinases
YJ Choi, L Anders - Oncogene, 2014 - nature.com
Research over the past quarter century has identified cyclin D-dependent kinases, CDK4
and CDK6, as the major oncogenic drivers among members of the CDK superfamily …
and CDK6, as the major oncogenic drivers among members of the CDK superfamily …
The requirement for cyclin D function in tumor maintenance
YJ Choi, X Li, P Hydbring, T Sanda, J Stefano… - Cancer cell, 2012 - cell.com
D-cyclins represent components of cell cycle machinery. To test the efficacy of targeting D-
cyclins in cancer treatment, we engineered mouse strains that allow acute and global …
cyclins in cancer treatment, we engineered mouse strains that allow acute and global …
Wnt signaling in the intestinal epithelium: from endoderm to cancer
A Gregorieff, H Clevers - Genes & development, 2005 - genesdev.cshlp.org
The Wnt pathway controls cell fate during embryonic development. It also persists as a key
regulator of homeostasis in adult self-renewing tissues. In these tissues, mutational …
regulator of homeostasis in adult self-renewing tissues. In these tissues, mutational …
Versatile nutraceutical potentials of watermelon—A modest fruit loaded with pharmaceutically valuable phytochemicals
A Manivannan, ES Lee, K Han, HE Lee, DS Kim - Molecules, 2020 - mdpi.com
Watermelon (Citrulus lantus) is an important horticultural crop which belongs to the
Curcubitaceae family. The nutraceutical potential of watermelon has been illustrated by …
Curcubitaceae family. The nutraceutical potential of watermelon has been illustrated by …
Cyclins and cell cycle control in cancer and disease
MC Casimiro, M Crosariol, E Loro, Z Li… - Genes & …, 2012 - journals.sagepub.com
Cyclin D1 overexpression is found in more than 50% of human breast cancers and causes
mammary cancer in transgenic mice. Dysregulation of cyclin D1 gene expression or function …
mammary cancer in transgenic mice. Dysregulation of cyclin D1 gene expression or function …
[HTML][HTML] New roles of cyclin D1
RG Pestell - The American journal of pathology, 2013 - Elsevier
Cyclins encode regulatory subunits of holoenzymes that phosphorylate a variety of cellular
substrates. Although the classic role of cyclins in cell cycle progression and tumorigenesis …
substrates. Although the classic role of cyclins in cell cycle progression and tumorigenesis …