The Brassicaceae family, known as cruciferous vegetables, includes many economically
important species, mainly edible oil plants, vegetable species, spice plants, and feed plants …

Cancer is characterized by uncontrolled tumour cell proliferation resulting from aberrant
activity of various cell cycle proteins. Therefore, cell cycle regulators are considered …

Entry into, progression through, and exit from the G1 phase of the mammalian cell cycle in
response to extracellular mitogenic cues are presumed to be governed by cyclin-dependent …

Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and
inactivates the retinoblastoma protein and promotes progression through the G1-S phase of …

Research over the past quarter century has identified cyclin D-dependent kinases, CDK4
and CDK6, as the major oncogenic drivers among members of the CDK superfamily …

D-cyclins represent components of cell cycle machinery. To test the efficacy of targeting D-
cyclins in cancer treatment, we engineered mouse strains that allow acute and global …

The Wnt pathway controls cell fate during embryonic development. It also persists as a key
regulator of homeostasis in adult self-renewing tissues. In these tissues, mutational …

Watermelon (Citrulus lantus) is an important horticultural crop which belongs to the
Curcubitaceae family. The nutraceutical potential of watermelon has been illustrated by …

Cyclin D1 overexpression is found in more than 50% of human breast cancers and causes
mammary cancer in transgenic mice. Dysregulation of cyclin D1 gene expression or function …

Cyclins encode regulatory subunits of holoenzymes that phosphorylate a variety of cellular
substrates. Although the classic role of cyclins in cell cycle progression and tumorigenesis …