A comprehensive review of chalcone derivatives as antileishmanial agents

MVP de Mello, B de Azevedo Abrahim-Vieira… - European journal of …, 2018 - Elsevier
Leishmaniasis is a group of infectious neglected tropical diseases caused by more than 20
pathogenic species of Leishmania sp. Due to the limitations of the current treatments …

Antileishmanial drug discovery: Comprehensive review of the last 10 years

JN Sangshetti, FAK Khan, AA Kulkarni, R Arote… - Rsc Advances, 2015 - pubs.rsc.org
Leishmaniasis, a group of diseases caused by hemoflagellate obligate intracellular protozoa
(trypanosomatids) from the genus Leishmania, has not received the attention it deserves …

A review on new natural and synthetic anti-leishmanial chemotherapeutic agents and current perspective of treatment approaches.

N Majumder, A Banerjee, S Saha - Acta Tropica, 2023 - Elsevier
Leishmaniases are considered among the most neglected yet dangerous parasitic diseases
worldwide. According to the recent WHO report (Weekly Epidemiological Record, Sep …

Identification of chalcone-based antileishmanial agents targeting trypanothione reductase

M Ortalli, A Ilari, G Colotti, I De Ionna, T Battista… - European journal of …, 2018 - Elsevier
All currently used first-line and second-line drugs for the treatment of leishmaniasis exhibit
several drawbacks including toxicity, high costs and route of administration. Furthermore …

Design, synthesis, cytotoxicity, HuTopoIIα inhibitory activity and molecular docking studies of pyrazole derivatives as potential anticancer agents

R Alam, D Wahi, R Singh, D Sinha, V Tandon… - Bioorganic …, 2016 - Elsevier
In an attempt to find potential anticancer agents, a series of novel ethyl 4-(3-(aryl)-1-phenyl-
1H-pyrazol-4-yl)-2-oxo-6-(pyridin-3-yl) cyclohex-3-enecarboxylates 5a-i and 5-(3-(4 …

Synthesis, structural characterization and computational study of a novel amino chalcone: a potential nonlinear optical material

LR Almeida, MM Anjos, GC Ribeiro… - New Journal of …, 2017 - pubs.rsc.org
The interest for novel chalcone-based materials in nonlinear optics is dependent on strong
second harmonic generation in organic systems. Chalcones are α, β-unsaturated ketones …

The chemotherapeutic potential of chalcones against leishmaniases: a review

N Tajuddeen, MB Isah, MA Suleiman… - International journal of …, 2018 - Elsevier
Leishmaniases are endemic diseases in tropical and sub-tropical regions of the world and
are considered by the World Health Organization (WHO) to be among the six most important …

[HTML][HTML] Identification of some chalcone analogues as potential antileishmanial agents: An integrated in vitro and in silico evaluation

MS Osman, TA Awad, SW Shantier… - Arabian Journal of …, 2022 - Elsevier
Chalcones, either natural or synthetic, are known to exhibit various biological activities. The
present study aimed to evaluate the in vitro and in silico activities of some chalcone …

Current therapeutics, their problems and thiol metabolism as potential drug targets in leishmaniasis

K Singh, G Garg, V Ali - Current drug metabolism, 2016 - ingentaconnect.com
Leishmaniasis is one of the six diseases regarded most neglected by World Health
Organization which is predominant in developing countries. Clinically, among the different …

Novel amino-pyrazole ureas with potent in vitro and in vivo antileishmanial activity

CE Mowbray, S Braillard, W Speed… - Journal of medicinal …, 2015 - ACS Publications
Visceral leishmaniasis is a severe parasitic disease that is one of the most neglected tropical
diseases. Treatment options are limited, and there is an urgent need for new therapeutic …