Anaplastic lymphoma kinase (ALK) alterations (activating mutations, amplifications, and
fusions/rearrangements) occur in~ 3.3% of cancers. ALK fusions/rearrangements are …

The anaplastic lymphoma kinase (ALK) gene plays an important physiologic role in the
development of the brain and can be oncogenically altered in several malignancies …

Anaplastic lymphoma kinase (ALK) is a member of the insulin receptor protein-tyrosine
kinase superfamily and was first discovered in anaplastic large-cell lymphoma (ALCL). ALK …

Activated anaplastic lymphoma kinase (ALK) and ROS1 tyrosine kinases, through gene
fusions, have been found in lung adenocarcinomas and are highly sensitive to selective …

Colorectal cancer (CRC) results from the accumulation of genetic alterations, and somatic
copy number alterations (CNAs) are crucial for the development of CRC. Genome-wide …

The invasive nature of surgical biopsies deters sequential application, and single biopsies
often fail to reflect tumor dynamics, intratumor heterogeneity and drug sensitivities likely to …

The treatment scenario of metastatic colorectal cancer (mCRC) has been rapidly enriched
with new chemotherapy combinations and biological agents that lead to a remarkable …

The duration and magnitude of clinical response are unpredictable in ALK-rearranged non–
small cell lung cancer (NSCLC) patients treated with crizotinib, although all patients …

Background Rhabdomyosarcoma (RMS) is the most commonly diagnosed malignant soft
tissue tumour in children and adolescents. Aberrant expression of Anaplastic Lymphoma …

Background Recent studies emphasize the role of BRAF as a genetic marker for prediction,
prognosis and risk stratification in colorectal cancer. Earlier studies have reported the …