Recent Advances and Future Developments in the Preparation of Polypeptides via N-Carboxyanhydride (NCA) Ring-Opening Polymerization

Y Wu, K Chen, J Wang, M Chen, W Dai… - Journal of the American …, 2024 - ACS Publications
Polypeptides have the same or similar backbone structures as proteins and peptides,
rendering them as suitable and important biomaterials. Amino acid N-carboxyanhydrides …

Combating bacterial infections with host defense peptides: shifting focus from bacteria to host immunity

N Gao, J Wang, C Fang, P Bai, Y Sun, W Wu… - Drug Resistance …, 2024 - Elsevier
The increasing prevalence of multidrug-resistant bacterial infections necessitates the
exploration of novel paradigms for anti-infective therapy. Antimicrobial peptides (AMPs), also …

Local delivery of glabridin by biomolecular microneedle to accelerate infected wound healing

Z Chen, T Hu, R Wang, B Huang, L Tu… - Advanced …, 2024 - Wiley Online Library
Applying antibacterial polymers and pro‐regenerative small molecules are two individual
strategies for accelerating wound healing. However, integrating those two unique …

Peptide-mimicking poly (2-oxazoline) s possessing potent antifungal activity and BBB penetrating property to treat invasive infections and meningitis

W Jiang, M Zhou, S Chen, J Xie, M Chen… - Journal of the …, 2023 - ACS Publications
Invasive fungal infections, including meningitis, cause a high mortality rate due to few
available antifungal drugs and frequently associated side effects and quick emergence of …

Structural Element of Vitamin U‐Mimicking Antibacterial Polypeptide with Ultrahigh Selectivity for Effectively Treating MRSA Infections

Z Zhang, X Wang, J Liu, H Yang, H Tang… - Angewandte Chemie …, 2024 - Wiley Online Library
Antimicrobial peptides (AMPs) exhibit mighty antibacterial properties without inducing drug
resistance. Achieving much higher selectivity of AMPs towards bacteria and normal cells has …

Open-vessel polymerization of N-carboxyanhydride (NCA) for polypeptide synthesis

Y Wu, K Chen, J Wang, W Dai, H Yu, X Xie, M Chen… - Nature …, 2024 - nature.com
Synthetic polypeptides, also known as poly (α-amino acids), have the same polyamide
backbone structures as natural proteins and peptides. As an important class of biomaterials …

[HTML][HTML] Shape matters: Effect of amphiphilic polymer topology on antibacterial activity and hemocompatibility

M Aquib, S Schaefer, H Gmedhin, N Corrigan… - European Polymer …, 2024 - Elsevier
Understanding the intricate relationship between polymer architecture and biological activity
is critical for advancing the development of antibacterial polymers. In this study, we …

Interface/Dipole Polarized Antibiotics‐Loaded Fe3O4/PB Nanoparticles for Non‐Invasive Therapy of Osteomyelitis Under Medical Microwave Irradiation

L Jin, H Liu, C Wang, C Mao, S Wu, Y Zhang… - Advanced …, 2024 - Wiley Online Library
Due to their poor light penetration, photothermal therapy and photodynamic therapy are
ineffective in treating deep tissue infections, such as osteomyelitis caused by …

Single-Center Trifunctional Organocatalyst Enables Fast and Controlled Polymerization on N-Carboxyanhydride

K Chen, Y Wu, M Chen, J Wang, M Zhou… - ACS Central …, 2024 - ACS Publications
Ring-opening polymerization on N-carboxyanhydrides (NCA) initiated by primary amines
has been the dominantly used method to prepare polypeptides with widespread …

Regulation of hydrophobic structures of antibacterial guanidinium-based amphiphilic polymers for subcutaneous implant applications

Y Rao, X Zou, X Shen, H Zhang, S Gao, J Guo… - …, 2023 - ACS Publications
Antimicrobial peptide mimics have been used to kill bacteria and construct antibacterial
materials. Precise design and construction of chemical structure are essential for easy …