Recent Advances and Future Developments in the Preparation of Polypeptides via N-Carboxyanhydride (NCA) Ring-Opening Polymerization
Polypeptides have the same or similar backbone structures as proteins and peptides,
rendering them as suitable and important biomaterials. Amino acid N-carboxyanhydrides …
rendering them as suitable and important biomaterials. Amino acid N-carboxyanhydrides …
Combating bacterial infections with host defense peptides: shifting focus from bacteria to host immunity
N Gao, J Wang, C Fang, P Bai, Y Sun, W Wu… - Drug Resistance …, 2024 - Elsevier
The increasing prevalence of multidrug-resistant bacterial infections necessitates the
exploration of novel paradigms for anti-infective therapy. Antimicrobial peptides (AMPs), also …
exploration of novel paradigms for anti-infective therapy. Antimicrobial peptides (AMPs), also …
Local delivery of glabridin by biomolecular microneedle to accelerate infected wound healing
Z Chen, T Hu, R Wang, B Huang, L Tu… - Advanced …, 2024 - Wiley Online Library
Applying antibacterial polymers and pro‐regenerative small molecules are two individual
strategies for accelerating wound healing. However, integrating those two unique …
strategies for accelerating wound healing. However, integrating those two unique …
Peptide-mimicking poly (2-oxazoline) s possessing potent antifungal activity and BBB penetrating property to treat invasive infections and meningitis
Invasive fungal infections, including meningitis, cause a high mortality rate due to few
available antifungal drugs and frequently associated side effects and quick emergence of …
available antifungal drugs and frequently associated side effects and quick emergence of …
Structural Element of Vitamin U‐Mimicking Antibacterial Polypeptide with Ultrahigh Selectivity for Effectively Treating MRSA Infections
Z Zhang, X Wang, J Liu, H Yang, H Tang… - Angewandte Chemie …, 2024 - Wiley Online Library
Antimicrobial peptides (AMPs) exhibit mighty antibacterial properties without inducing drug
resistance. Achieving much higher selectivity of AMPs towards bacteria and normal cells has …
resistance. Achieving much higher selectivity of AMPs towards bacteria and normal cells has …
Open-vessel polymerization of N-carboxyanhydride (NCA) for polypeptide synthesis
Synthetic polypeptides, also known as poly (α-amino acids), have the same polyamide
backbone structures as natural proteins and peptides. As an important class of biomaterials …
backbone structures as natural proteins and peptides. As an important class of biomaterials …
[HTML][HTML] Shape matters: Effect of amphiphilic polymer topology on antibacterial activity and hemocompatibility
Understanding the intricate relationship between polymer architecture and biological activity
is critical for advancing the development of antibacterial polymers. In this study, we …
is critical for advancing the development of antibacterial polymers. In this study, we …
Interface/Dipole Polarized Antibiotics‐Loaded Fe3O4/PB Nanoparticles for Non‐Invasive Therapy of Osteomyelitis Under Medical Microwave Irradiation
Due to their poor light penetration, photothermal therapy and photodynamic therapy are
ineffective in treating deep tissue infections, such as osteomyelitis caused by …
ineffective in treating deep tissue infections, such as osteomyelitis caused by …
Single-Center Trifunctional Organocatalyst Enables Fast and Controlled Polymerization on N-Carboxyanhydride
Ring-opening polymerization on N-carboxyanhydrides (NCA) initiated by primary amines
has been the dominantly used method to prepare polypeptides with widespread …
has been the dominantly used method to prepare polypeptides with widespread …
Regulation of hydrophobic structures of antibacterial guanidinium-based amphiphilic polymers for subcutaneous implant applications
Y Rao, X Zou, X Shen, H Zhang, S Gao, J Guo… - …, 2023 - ACS Publications
Antimicrobial peptide mimics have been used to kill bacteria and construct antibacterial
materials. Precise design and construction of chemical structure are essential for easy …
materials. Precise design and construction of chemical structure are essential for easy …