Short-chain fatty acids (SCFAs), mainly including acetate, propionate, and butyrate, are
metabolites produced during the bacterial fermentation of dietary fiber in the intestinal tract …

The past decade has seen the emergence of immunotherapy as a prime approach to cancer
treatment, revolutionizing the management of many types of cancer. Despite the promise of …

Post-translational modification (PTM) in histone proteins is a covalent modification which
mainly consists of methylation, phosphorylation, acetylation, ubiquitylation, SUMOylation …

The ability of tumor cells to adapt to changes in oxygen tension is essential for tumor
development. Low oxygen concentration influences cellular metabolism and, thus, affects …

Human gut microbiota has been increasingly recognized as a pivotal determinant of non-
alcoholic fatty liver disease (NAFLD). Apart from the changes in the composition of gut …

Cells primarily rely on proteins to perform the majority of their physiological functions, and
the function of proteins is regulated by post‑translational modifications (PTMs). The …

Over the last decade, numerous histone acyl post-translational modifications (acyl-PTMs)
have been discovered, of which the functional significance is still under intense study. Here …

BACKGROUND: Chromatin remodeling, including changes in histone acetylation, might
play a role in the pathophysiology and treatment of depression. We investigated whether the …

Histone deacetylase 8 (HDAC8) is a class I HDAC that catalyzes the deacetylation of histone
and non-histone proteins. As one of the best-characterized isoforms, numerous studies have …

The long-term consequences of early environmental experiences for development have
been explored extensively in animal models to better understand the mechanisms mediating …