Obstacles and opportunities in a forward vision for cancer nanomedicine
I de Lázaro, DJ Mooney - Nature materials, 2021 - nature.com
Cancer nanomedicines were initially envisioned as magic bullets, travelling through the
circulation to target tumours while sparing healthy tissues the toxicity of classic …
circulation to target tumours while sparing healthy tissues the toxicity of classic …
Polyethylene glycol (PEG): The nature, immunogenicity, and role in the hypersensitivity of PEGylated products
Polyethylene glycol (PEG) is a versatile polymer that is widely used as an additive in foods
and cosmetics, and as a carrier in PEGylated therapeutics. Even though PEG is thought to …
and cosmetics, and as a carrier in PEGylated therapeutics. Even though PEG is thought to …
[HTML][HTML] Recent progress in nanomedicine for enhanced cancer chemotherapy
G Wei, Y Wang, G Yang, Y Wang, R Ju - Theranostics, 2021 - ncbi.nlm.nih.gov
As one of the most important cancer treatment strategies, conventional chemotherapy has
substantial side effects and leads easily to cancer treatment failure. Therefore, exploring and …
substantial side effects and leads easily to cancer treatment failure. Therefore, exploring and …
Engineered nanomedicines with enhanced tumor penetration
Nanomedicine has been extensively explored to enhance the efficacy of chemotherapy with
modest therapeutic efficacy in the clinic, owing to various factors. A primary factor is …
modest therapeutic efficacy in the clinic, owing to various factors. A primary factor is …
Extracellular matrix-based materials for regenerative medicine
GS Hussey, JL Dziki, SF Badylak - Nature Reviews Materials, 2018 - nature.com
In tissue engineering and regenerative medicine, a biomaterial provides mechanical support
and biochemical signals to encourage cell attachment and modulate cell behaviour …
and biochemical signals to encourage cell attachment and modulate cell behaviour …
Cancer nanomedicine: a review of recent success in drug delivery
Cancer continues to be one of the most difficult global healthcare problems. Although there
is a large library of drugs that can be used in cancer treatment, the problem is selectively …
is a large library of drugs that can be used in cancer treatment, the problem is selectively …
Advanced liposome and polymersome-based drug delivery systems: Considerations for physicochemical properties, targeting strategies and stimuli-sensitive …
Liposomes and polymersomes are colloidal vesicles that are self-assembled from lipids and
amphiphilic polymers, respectively. Because of their ability to encapsulate both hydrophilic …
amphiphilic polymers, respectively. Because of their ability to encapsulate both hydrophilic …
Rational design of cancer nanomedicine: nanoproperty integration and synchronization
Current cancer nanomedicines can only mitigate adverse effects but fail to enhance
therapeutic efficacies of anticancer drugs. Rational design of next‐generation cancer …
therapeutic efficacies of anticancer drugs. Rational design of next‐generation cancer …
Physical properties of nanoparticles that result in improved cancer targeting
R Zein, W Sharrouf, K Selting - Journal of Oncology, 2020 - Wiley Online Library
The therapeutic efficacy of drugs is dependent upon the ability of a drug to reach its target,
and drug penetration into tumors is limited by abnormal vasculature and high interstitial …
and drug penetration into tumors is limited by abnormal vasculature and high interstitial …
Nanomaterials for in vivo imaging
BR Smith, SS Gambhir - Chemical reviews, 2017 - ACS Publications
In vivo imaging, which enables us to peer deeply within living subjects, is producing
tremendous opportunities both for clinical diagnostics and as a research tool. Contrast …
tremendous opportunities both for clinical diagnostics and as a research tool. Contrast …