Diffuse large B-cell lymphoma

LH Sehn, G Salles - New England Journal of Medicine, 2021 - Mass Medical Soc
Diffuse Large B-Cell Lymphoma DLBCL, an aggressive cancer, accounts for about 30% of
all lymphomas. Empirical combination chemotherapy cures about 65% of patients initially …

CAR T cells as a second-line therapy for large B-cell lymphoma: a paradigm shift?

J Westin, LH Sehn - Blood, The Journal of the American Society …, 2022 - ashpublications.org
The standard of care treatment strategy for patients with relapsed or refractory large B-cell
lymphoma (LBCL) has been high-dose chemotherapy followed by autologous stem cell …

Lisocabtagene maraleucel versus standard of care with salvage chemotherapy followed by autologous stem cell transplantation as second-line treatment in patients …

M Kamdar, SR Solomon, J Arnason, PB Johnston… - The Lancet, 2022 - thelancet.com
Background Patients with large B-cell lymphoma (LBCL) primary refractory to or relapsed
within 12 months of first-line therapy are at high risk for poor outcomes with current standard …

[HTML][HTML] Axicabtagene ciloleucel as second-line therapy for large B-cell lymphoma

FL Locke, DB Miklos, CA Jacobson… - … England Journal of …, 2022 - Mass Medical Soc
Background The prognosis of patients with early relapsed or refractory large B-cell
lymphoma after the receipt of first-line chemoimmunotherapy is poor. Methods In this …

[HTML][HTML] Second-line tisagenlecleucel or standard care in aggressive B-cell lymphoma

MR Bishop, M Dickinson, D Purtill… - … England Journal of …, 2022 - Mass Medical Soc
Background Patient outcomes are poor for aggressive B-cell non-Hodgkin's lymphomas not
responding to or progressing within 12 months after first-line therapy. Tisagenlecleucel is an …

Lisocabtagene maraleucel as second-line therapy for large B-cell lymphoma: primary analysis of the phase 3 TRANSFORM study

JS Abramson, SR Solomon, J Arnason, PB Johnston… - Blood, 2023 - ashpublications.org
This global phase 3 study compared lisocabtagene maraleucel (liso-cel) with a standard of
care (SOC) as second-line therapy for primary refractory or early relapsed (≤ 12 months) …

[HTML][HTML] Tisagenlecleucel in adult relapsed or refractory diffuse large B-cell lymphoma

SJ Schuster, MR Bishop, CS Tam… - … England Journal of …, 2019 - Mass Medical Soc
Background Patients with diffuse large B-cell lymphoma that is refractory to primary and
second-line therapies or that has relapsed after stem-cell transplantation have a poor …

Lisocabtagene maraleucel as second-line therapy in adults with relapsed or refractory large B-cell lymphoma who were not intended for haematopoietic stem cell …

A Sehgal, D Hoda, PA Riedell, N Ghosh… - The Lancet …, 2022 - thelancet.com
Background Patients with relapsed or refractory large B-cell lymphoma after first-line
treatment who are not intended for haematopoietic stem-cell transplantation (HSCT) have …

Outcomes in refractory diffuse large B-cell lymphoma: results from the international SCHOLAR-1 study

M Crump, SS Neelapu, U Farooq… - Blood, The Journal …, 2017 - ashpublications.org
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin
lymphoma. Although 5-year survival rates in the first-line setting range from 60% to 70%, up …

Diffuse large B-cell lymphoma

S Li, KH Young, LJ Medeiros - Pathology, 2018 - Elsevier
Diffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma
worldwide, representing approximately 30–40% of all cases in different geographic regions …