Despite rapid progresses in the genome-editing field, in vivo simultaneous overexpression
of multiple genes remains challenging. We generated a transgenic mouse using an …

Vertebrate segmentation relies on a mechanism characterized by oscillating gene
expression. Whether this mechanism is used by other segmented animals has been …

Tribolium castaneum is a small, low-maintenance beetle that has emerged as a
sophisticated model system for studying the evolution of development and that complements …

One of the key morphogenetic processes used during development is the controlled
intercalation of cells between their neighbors. This process has been co-opted into a range …

Background The red flour beetle Tribolium castaneum has developed into an insect model
system second only to Drosophila. Moreover, as a coleopteran it represents the most …

Long-germ insects, such as the fruit fly Drosophila melanogaster, pattern their segments
simultaneously, whereas short-germ insects, such as the beetle Tribolium castaneum …

Tribolium castaneum is exceptionally amenable to gene knockdown by RNA interference
(RNAi) which, in this insect, is systemic (spreading throughout the organism and to the next …

Several highly conserved genes play a role in anterior neural plate patterning of vertebrates
and in head and brain patterning of insects. However, head involution in Drosophila has …

Canonical Wnt signaling has been implicated in an AP axis polarizing mechanism in most
animals, despite limited evidence from arthropods. In the long-germ insect, Drosophila, Wnt …

Chemical defense is one of the most important traits, which endow insects the ability to
conquer a most diverse set of ecological environments. Chemical secretions are used for …