Mycovirus diversity and evolution revealed/inferred from recent studies

H Kondo, L Botella, N Suzuki - Annual Review of …, 2022 - annualreviews.org
High-throughput virome analyses with various fungi, from cultured or uncultured sources,
have led to the discovery of diverse viruses with unique genome structures and even neo …

Terpenes and terpenoids in plants: Interactions with environment and insects

DAT Boncan, SSK Tsang, C Li, IHT Lee… - International Journal of …, 2020 - mdpi.com
The interactions of plants with environment and insects are bi-directional and dynamic.
Consequently, a myriad of mechanisms has evolved to engage organisms in different types …

Introducing the bacterial and viral bioinformatics resource center (BV-BRC): a resource combining PATRIC, IRD and ViPR

RD Olson, R Assaf, T Brettin, N Conrad… - Nucleic acids …, 2023 - academic.oup.com
Abstract The National Institute of Allergy and Infectious Diseases (NIAID) established the
Bioinformatics Resource Center (BRC) program to assist researchers with analyzing the …

Predicting multiple conformations via sequence clustering and AlphaFold2

HK Wayment-Steele, A Ojoawo, R Otten, JM Apitz… - Nature, 2024 - nature.com
Abstract AlphaFold2 (ref.) has revolutionized structural biology by accurately predicting
single structures of proteins. However, a protein's biological function often depends on …

Super-pangenome analyses highlight genomic diversity and structural variation across wild and cultivated tomato species

N Li, Q He, J Wang, B Wang, J Zhao, S Huang… - Nature Genetics, 2023 - nature.com
Effective utilization of wild relatives is key to overcoming challenges in genetic improvement
of cultivated tomato, which has a narrow genetic basis; however, current efforts to decipher …

[HTML][HTML] Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM

TV Lanz, RC Brewer, PP Ho, JS Moon, KM Jude… - Nature, 2022 - nature.com
Multiple sclerosis (MS) is a heterogenous autoimmune disease in which autoreactive
lymphocytes attack the myelin sheath of the central nervous system. B lymphocytes in the …

Genome-scale metabolic reconstruction of 7,302 human microorganisms for personalized medicine

A Heinken, J Hertel, G Acharya, DA Ravcheev… - Nature …, 2023 - nature.com
The human microbiome influences the efficacy and safety of a wide variety of commonly
prescribed drugs. Designing precision medicine approaches that incorporate microbial …

Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant

B Li, A Deng, K Li, Y Hu, Z Li, Y Shi, Q Xiong… - Nature …, 2022 - nature.com
Abstract The SARS-CoV-2 Delta variant has spread rapidly worldwide. To provide data on
its virological profile, we here report the first local transmission of Delta in mainland China …

Emergence of methicillin resistance predates the clinical use of antibiotics

J Larsen, CL Raisen, X Ba, NJ Sadgrove… - Nature, 2022 - nature.com
The discovery of antibiotics more than 80 years ago has led to considerable improvements
in human and animal health. Although antibiotic resistance in environmental bacteria is …

Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models

AA Cohen, N van Doremalen, AJ Greaney, H Andersen… - Science, 2022 - science.org
To combat future severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
and spillovers of SARS-like betacoronaviruses (sarbecoviruses) threatening global health …