Integrins are activatable molecules that are involved in adhesion and signalling. Of the 24
known human integrins, 3 are currently targeted therapeutically by monoclonal antibodies …

The integrins are a large family of cell adhesion molecules that are essential for the
regulation of cell growth and function. The identification of key roles for integrins in a diverse …

Integrins are transmembrane receptors that are central to the biology of many human
pathologies. Classically mediating cell-extracellular matrix and cell-cell interaction, and with …

Drug-induced immune thrombocytopenia (DITP) can be triggered by a wide range of
medications. Although many cases of DITP are mild, some are characterized by life …

Platelet aggregation is a critical event in thrombus formation and thus has extensive
involvement in physiological and pathological processes. The aggregation response …

Drug-induced immune thrombocytopenia (DITP) is a challenging clinical problem that is
under-recognized, difficult to diagnose and associated with severe bleeding complications …

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Hantaviruses cause two vascular permeability-based diseases and primarily infect
endothelial cells which form the primary fluid barrier of the vasculature. Since hantavirus …

Activation of latent transforming growth factor (TGF)-β2 is incompletely understood. Unlike
TGF-β1 and β3, the TGF-β2 prodomain lacks a seven-residue RGDLXX (L/I) integrin …

From the discovery of the platelet glycoprotein (GP) IIb/IIIa and identification of its central role
in haemostasis, the integrin GPIIb/IIIa (αIIbβ3, CD41/CD61) was destined to be an anti …