Exploring the recent pioneering developments of small molecules in antimalarial drug armamentarium: A chemistry prospective appraisal
T Bagratee, R Prawlall, T Ndlovu, S Sibisi… - Chemistry & …, 2024 - Wiley Online Library
Malaria is a very destructive and lethal parasitic disease that causes significant mortality
worldwide, resulting in the loss of millions of lives annually. It is an infectious disease …
worldwide, resulting in the loss of millions of lives annually. It is an infectious disease …
Post-Translational Modifications of Proteins of Malaria Parasites during the Life Cycle
E Schwarzer, O Skorokhod - International Journal of Molecular Sciences, 2024 - mdpi.com
Post-translational modifications (PTMs) are essential for regulating protein functions,
influencing various fundamental processes in eukaryotes. These include, but are not limited …
influencing various fundamental processes in eukaryotes. These include, but are not limited …
Sulfonamide based pyrimidine derivatives combating Plasmodium parasite by inhibiting falcipains-2 and falcipains-3 as antimalarial agents
In this report, we present the design and synthesis of a novel series of pyrimidine-tethered
spirochromane-based sulfonamide derivatives aimed at combating drug resistance in …
spirochromane-based sulfonamide derivatives aimed at combating drug resistance in …
Reinvestigation of diphenylmethylpiperazine analogues of pyrazine as new class of Plasmodial cysteine protease inhibitors for the treatment of malaria
Malaria eradication is still a global challenge due to the lack of a broadly effective vaccine
and the emergence of drug resistance to most of the currently available drugs as part of the …
and the emergence of drug resistance to most of the currently available drugs as part of the …
Identifying Thiourea-Based Hybrids of Quinazoline and Oxospirochromane as Inhibitors of Plasmodium Cysteine Proteases Arresting the Parasitic Growth at the Early …
Malaria, an infectious disease, impacts approximately half of the global population. To tackle
the growing problem of drug resistance to treatments such as artemisinin-based …
the growing problem of drug resistance to treatments such as artemisinin-based …
Diversity-Oriented Repurposing of Pyrimidin-4-yl) oxy) methyl)-1H-1, 2, 3-triazol-1-yl) benzenesulfonamides as Promising Antifungals that inhibit Ergosterol …
Mortality and morbidity rates are rising globally in transplant surgery patients due to drug-
resistant fungi, toxic antifungal drugs, and a lack of new treatments. Repurposing existing …
resistant fungi, toxic antifungal drugs, and a lack of new treatments. Repurposing existing …